Motif ID: Gli2

Z-value: 0.572


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_1190536380.782.3e-06Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_72788952 2.823 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr6_-_72789240 2.798 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr6_-_23248264 1.934 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_144738520 1.608 ENSMUST00000118556.2
ENSMUST00000033393.8
 Ano1

anoctamin 1, calcium activated chloride channel

chr7_-_4752972 1.594 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr3_-_135608221 1.569 ENSMUST00000132668.1
 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chrX_+_137049586 1.550 ENSMUST00000047852.7
 Fam199x
family with sequence similarity 199, X-linked
chr5_-_24527276 1.518 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr7_-_137314394 1.464 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chrX_-_141725181 1.440 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr7_-_116308241 1.342 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr9_-_43239816 1.282 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr7_-_144738478 1.209 ENSMUST00000121758.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr8_+_127064022 1.174 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr6_+_120666388 1.160 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr4_+_124700700 1.131 ENSMUST00000106199.3
ENSMUST00000038684.5
 Fhl3

four and a half LIM domains 3

chr13_+_35741313 1.130 ENSMUST00000163595.2
 Cdyl
chromodomain protein, Y chromosome-like
chrX_-_167382747 1.093 ENSMUST00000026839.4
 Prps2
phosphoribosyl pyrophosphate synthetase 2
chr8_+_127063893 1.090 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr5_+_117319292 1.080 ENSMUST00000086464.4
 Vsig10
V-set and immunoglobulin domain containing 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.6 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.5 3.2 GO:0003383 apical constriction(GO:0003383)
0.6 2.8 GO:0015705 iodide transport(GO:0015705)
0.4 2.0 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.3 1.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 1.6 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.4 1.5 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 1.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 1.4 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.2 1.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.2 GO:0001842 neural fold formation(GO:0001842)
0.2 1.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 1.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.2 0.8 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.1 0.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.8 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0005667 transcription factor complex(GO:0005667)
0.4 3.2 GO:0033269 internode region of axon(GO:0033269)
0.1 2.1 GO:0097470 ribbon synapse(GO:0097470)
0.2 1.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.6 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)
0.3 1.2 GO:0090537 CERF complex(GO:0090537)
0.3 1.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 1.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.5 GO:0071203 WASH complex(GO:0071203)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0008013 beta-catenin binding(GO:0008013)
0.1 4.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7 2.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.5 1.6 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.6 GO:0042805 actinin binding(GO:0042805)
0.0 1.4 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 1.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.2 GO:0005158 insulin receptor binding(GO:0005158)
0.3 1.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.8 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 0.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 0.7 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)