Motif ID: Gli3_Zic1

Z-value: 1.537

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463837_15463980-0.831.5e-07Click!
Zic1mm10_v2_chr9_-_91365756_91365774-0.281.7e-01Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_50752758 7.158 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr16_+_91269759 6.569 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr4_+_124657646 6.415 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr2_-_29253001 5.411 ENSMUST00000071201.4
 Ntng2
netrin G2
chr4_-_148130678 5.392 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr7_+_99268338 5.366 ENSMUST00000107100.2
 Map6
microtubule-associated protein 6
chr6_-_101377897 5.213 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr11_-_42000284 5.188 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr2_-_36104060 5.075 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr11_-_42000532 5.042 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr8_+_70501116 5.041 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr15_-_95528228 5.019 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr1_-_133801031 4.990 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr6_+_17463749 4.129 ENSMUST00000115443.1
 Met
met proto-oncogene
chr17_-_24209377 3.715 ENSMUST00000024931.4
 Ntn3
netrin 3
chr7_-_142657466 3.701 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr8_+_76902277 3.581 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr6_+_110645572 3.532 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr11_-_116654245 3.461 ENSMUST00000021166.5
 Cygb
cytoglobin
chr4_-_136956784 3.350 ENSMUST00000030420.8
 Epha8
Eph receptor A8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 15.6 GO:0071420 cellular response to histamine(GO:0071420)
1.3 11.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.7 7.9 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
1.2 7.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 6.6 GO:0048663 neuron fate commitment(GO:0048663)
0.1 6.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 6.4 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 6.3 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.9 5.8 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.3 5.4 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 5.4 GO:0032418 lysosome localization(GO:0032418)
0.1 5.4 GO:0008542 visual learning(GO:0008542)
0.9 5.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.8 5.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 5.0 GO:0007416 synapse assembly(GO:0007416)
0.2 4.7 GO:0002076 osteoblast development(GO:0002076)
0.7 4.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.6 4.4 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.3 4.4 GO:0001553 luteinization(GO:0001553)
1.4 4.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 10.1 GO:0009925 basal plasma membrane(GO:0009925)
0.2 8.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 8.0 GO:0045211 postsynaptic membrane(GO:0045211)
2.5 7.6 GO:0097512 cardiac myofibril(GO:0097512)
0.1 7.2 GO:0031594 neuromuscular junction(GO:0031594)
0.3 6.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.7 GO:0043204 perikaryon(GO:0043204)
0.2 5.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 5.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.7 5.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.3 5.0 GO:0097228 sperm principal piece(GO:0097228)
0.4 4.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.9 4.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 4.3 GO:0030673 axolemma(GO:0030673)
0.0 4.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 3.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 3.8 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.6 GO:0004890 GABA-A receptor activity(GO:0004890)
2.5 10.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 6.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 6.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 5.9 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 5.4 GO:0008201 heparin binding(GO:0008201)
0.4 5.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 5.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.7 5.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.5 4.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 4.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.5 4.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.7 4.4 GO:0016917 G-protein coupled GABA receptor activity(GO:0004965) GABA receptor activity(GO:0016917)
0.1 4.1 GO:0005262 calcium channel activity(GO:0005262)
0.6 3.9 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 3.9 GO:0030276 clathrin binding(GO:0030276)
0.5 3.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 3.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
1.2 3.5 GO:0070905 serine binding(GO:0070905)
0.9 3.5 GO:0004096 catalase activity(GO:0004096)