Motif ID: Glis2

Z-value: 0.889


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.213.1e-01Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 181 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_66981279 4.823 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr3_+_87948666 4.483 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr8_-_91801547 4.434 ENSMUST00000093312.4
 Irx3
Iroquois related homeobox 3 (Drosophila)
chr8_-_91801948 3.944 ENSMUST00000175795.1
 Irx3
Iroquois related homeobox 3 (Drosophila)
chr19_+_55741810 3.658 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_+_115059507 2.795 ENSMUST00000162489.1
 Tal1
T cell acute lymphocytic leukemia 1
chr7_-_103843154 2.085 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr5_+_136083916 1.543 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr5_+_136084022 1.425 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr1_-_172329261 1.419 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr8_-_87472576 1.356 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr5_-_30105359 1.295 ENSMUST00000127749.3
 3110082J24Rik
RIKEN cDNA 3110082J24 gene
chr2_-_57113053 1.208 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr8_+_58911755 1.169 ENSMUST00000062978.6
 BC030500
cDNA sequence BC030500
chr2_-_57124003 1.144 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr7_-_126704736 1.133 ENSMUST00000131415.1
 Coro1a
coronin, actin binding protein 1A
chr2_-_26294550 1.110 ENSMUST00000057224.3
 4932418E24Rik
RIKEN cDNA 4932418E24 gene
chr3_+_130180882 0.996 ENSMUST00000106353.1
ENSMUST00000080335.4
 Col25a1

collagen, type XXV, alpha 1

chr19_+_7268296 0.977 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr6_-_48840988 0.963 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0007498 mesoderm development(GO:0007498)
0.7 6.6 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.4 5.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.5 3.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.5 3.7 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 3.0 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.9 2.8 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.6 2.4 GO:0051866 general adaptation syndrome(GO:0051866)
0.4 2.1 GO:0015671 oxygen transport(GO:0015671)
0.3 1.8 GO:0032796 uropod organization(GO:0032796)
0.1 1.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.4 GO:0010107 potassium ion import(GO:0010107)
0.2 1.0 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.2 0.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) retinal rod cell differentiation(GO:0060221)
0.1 0.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.9 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040) negative regulation of protein folding(GO:1903333)
0.2 0.8 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.8 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.8 GO:0021796 cerebral cortex regionalization(GO:0021796)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 3.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.9 2.8 GO:0033193 Lsd1/2 complex(GO:0033193)
0.3 2.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.3 2.1 GO:0005833 hemoglobin complex(GO:0005833)
0.0 2.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.6 GO:0016235 aggresome(GO:0016235)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.7 GO:0009986 cell surface(GO:0009986)
0.1 0.6 GO:0044306 neuron projection terminus(GO:0044306)
0.1 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.5 GO:0090537 CERF complex(GO:0090537)
0.1 0.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.7 4.5 GO:0019841 retinol binding(GO:0019841)
0.2 3.7 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.8 GO:0070888 E-box binding(GO:0070888)
0.1 2.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 2.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.5 2.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 1.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.6 GO:0005112 Notch binding(GO:0005112)
0.3 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 0.9 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 0.7 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.7 GO:0042165 neurotransmitter binding(GO:0042165)
0.2 0.6 GO:0042289 MHC class II protein binding(GO:0042289)