Motif ID: Glis3

Z-value: 0.633


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_28680122-0.029.1e-01Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_66981279 2.803 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr7_-_49636847 2.210 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr4_-_134018829 1.878 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr6_+_88198656 1.562 ENSMUST00000015197.7
 Gata2
GATA binding protein 2
chr7_-_142899985 1.333 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr13_-_40730416 1.082 ENSMUST00000021787.5
 Tfap2a
transcription factor AP-2, alpha
chr12_+_109743787 1.009 ENSMUST00000183068.1
 Mirg
miRNA containing gene
chr11_-_102296618 0.831 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr7_-_142657466 0.791 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr13_+_38345716 0.729 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr9_-_48835932 0.700 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr5_-_24527276 0.566 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr2_+_32646586 0.555 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr3_+_66981352 0.481 ENSMUST00000162036.1
 Rsrc1
arginine/serine-rich coiled-coil 1
chr10_-_68278713 0.432 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr1_+_167001457 0.404 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr8_-_87959560 0.393 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_+_17463749 0.381 ENSMUST00000115443.1
 Met
met proto-oncogene
chr11_+_3289880 0.377 ENSMUST00000110043.1
ENSMUST00000094471.3
 Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr9_-_108305941 0.373 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742) regulation of branching morphogenesis of a nerve(GO:2000172)
0.1 2.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 1.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.5 1.6 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.3 1.3 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 1.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.4 1.1 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.1 0.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.8 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.7 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.1 0.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.2 0.6 GO:0003032 detection of oxygen(GO:0003032)
0.1 0.6 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.4 GO:0046898 response to cycloheximide(GO:0046898)
0.0 0.4 GO:0060613 fat pad development(GO:0060613)
0.0 0.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.4 GO:0051602 response to electrical stimulus(GO:0051602)
0.0 0.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.1 0.8 GO:0016589 NURF complex(GO:0016589)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0001650 fibrillar center(GO:0001650)
0.1 0.2 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.0 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0035198 miRNA binding(GO:0035198)
0.1 1.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 1.3 GO:0035240 dopamine binding(GO:0035240)
0.3 1.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.2 0.6 GO:0005534 galactose binding(GO:0005534)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.3 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 0.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.2 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)