Motif ID: Gmeb1

Z-value: 0.601


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.765.6e-06Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_175880775 2.672 ENSMUST00000039725.6
 Exo1
exonuclease 1
chr3_+_127553462 2.641 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr3_+_40800054 2.526 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr6_+_113531675 2.361 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr2_-_157007039 2.158 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr3_+_40800013 2.153 ENSMUST00000026858.5
ENSMUST00000170825.1
 Plk4

polo-like kinase 4

chr2_-_157007015 1.936 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr2_+_75659253 1.758 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr11_-_40733373 1.540 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr17_+_84511832 1.407 ENSMUST00000047206.5
 Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr3_+_138143429 1.384 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chr15_-_58135047 1.338 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr15_+_99074968 1.288 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr3_+_138143483 1.288 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr19_+_43612299 1.248 ENSMUST00000057178.9
 Nkx2-3
NK2 homeobox 3
chrX_+_112311334 1.205 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr11_-_100822525 1.084 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr8_-_94918012 1.021 ENSMUST00000077955.5
 Ccdc102a
coiled-coil domain containing 102A
chr17_+_23679363 0.978 ENSMUST00000024699.2
 Cldn6
claudin 6
chr3_-_138143352 0.938 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr4_-_40269778 0.889 ENSMUST00000042575.6
 Topors
topoisomerase I binding, arginine/serine-rich
chr8_-_25016901 0.818 ENSMUST00000084035.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr11_+_40733639 0.811 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr3_-_127553233 0.793 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chr8_-_25016743 0.772 ENSMUST00000084032.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr13_-_53473074 0.761 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr15_-_99087817 0.637 ENSMUST00000064462.3
 C1ql4
complement component 1, q subcomponent-like 4
chr11_+_51263114 0.632 ENSMUST00000093132.6
ENSMUST00000109113.1
 Clk4

CDC like kinase 4

chr12_-_31654767 0.617 ENSMUST00000020977.2
 Dus4l
dihydrouridine synthase 4-like (S. cerevisiae)
chr2_+_69723071 0.614 ENSMUST00000040915.8
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr12_+_4917376 0.581 ENSMUST00000045664.5
 Atad2b
ATPase family, AAA domain containing 2B
chr4_+_55350043 0.572 ENSMUST00000030134.8
 Rad23b
RAD23b homolog (S. cerevisiae)
chr9_-_48495321 0.565 ENSMUST00000170000.2
 Rbm7
RNA binding motif protein 7
chr8_+_26119361 0.490 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
 Rnf170



ring finger protein 170



chr4_-_135353126 0.466 ENSMUST00000030613.4
ENSMUST00000131373.1
 Srrm1

serine/arginine repetitive matrix 1

chr4_-_126202583 0.460 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chr4_-_126202757 0.460 ENSMUST00000080919.5
 Thrap3
thyroid hormone receptor associated protein 3
chr11_-_86544754 0.460 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
 Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr4_-_135353164 0.458 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
 Srrm1


serine/arginine repetitive matrix 1


chr18_+_23954668 0.441 ENSMUST00000060762.4
 Zfp397
zinc finger protein 397
chr7_+_35397046 0.440 ENSMUST00000079414.5
 Cep89
centrosomal protein 89
chr11_+_53770458 0.414 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
 Irf1



interferon regulatory factor 1



chr8_-_45333189 0.414 ENSMUST00000095328.4
 Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
chr5_-_31291026 0.402 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr4_+_128727585 0.392 ENSMUST00000106079.3
ENSMUST00000133439.1
 Phc2

polyhomeotic-like 2 (Drosophila)

chr2_+_69722797 0.384 ENSMUST00000090858.3
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr15_-_81399594 0.382 ENSMUST00000023039.8
 St13
suppression of tumorigenicity 13
chr8_+_26119611 0.335 ENSMUST00000140819.1
 Rnf170
ring finger protein 170
chr9_-_45906837 0.305 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
 Rnf214


ring finger protein 214


chr14_+_32085804 0.294 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
 Oxnad1


oxidoreductase NAD-binding domain containing 1


chr11_+_69914179 0.291 ENSMUST00000057884.5
 Gps2
G protein pathway suppressor 2
chrX_+_150588223 0.285 ENSMUST00000153221.1
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr17_+_83350925 0.282 ENSMUST00000096766.4
ENSMUST00000112363.2
ENSMUST00000049503.8
 Eml4


echinoderm microtubule associated protein like 4


chr4_-_72200833 0.269 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
 Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr11_-_74724670 0.261 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr16_+_49699198 0.249 ENSMUST00000046777.4
ENSMUST00000142682.1
 Ift57

intraflagellar transport 57

chr11_-_6626030 0.244 ENSMUST00000000394.7
ENSMUST00000136682.1
 Tbrg4

transforming growth factor beta regulated gene 4

chr11_+_86544982 0.240 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr17_-_56626872 0.240 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr11_-_97782409 0.218 ENSMUST00000103146.4
 Rpl23
ribosomal protein L23
chr1_-_160212864 0.210 ENSMUST00000014370.5
 Cacybp
calcyclin binding protein
chr1_+_82316452 0.180 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr3_+_95434386 0.171 ENSMUST00000102749.4
ENSMUST00000090804.5
ENSMUST00000107161.1
ENSMUST00000107160.1
ENSMUST00000015666.10
 Arnt




aryl hydrocarbon receptor nuclear translocator




chr18_-_53744509 0.168 ENSMUST00000049811.6
 Cep120
centrosomal protein 120
chr11_-_113751309 0.152 ENSMUST00000106616.1
 Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr15_+_102073773 0.150 ENSMUST00000169681.1
 Eif4b
eukaryotic translation initiation factor 4B
chr13_+_49653297 0.144 ENSMUST00000021824.7
 Nol8
nucleolar protein 8
chr16_+_20548577 0.137 ENSMUST00000003319.5
 Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr15_+_81400132 0.125 ENSMUST00000163754.1
ENSMUST00000041609.4
 Xpnpep3

X-prolyl aminopeptidase (aminopeptidase P) 3, putative

chr15_-_81400043 0.123 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
 St13


suppression of tumorigenicity 13


chr7_-_111082997 0.121 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
 Eif4g2



eukaryotic translation initiation factor 4, gamma 2



chr11_+_22990519 0.100 ENSMUST00000173867.1
ENSMUST00000020562.4
 Cct4

chaperonin containing Tcp1, subunit 4 (delta)

chr8_-_123949201 0.092 ENSMUST00000044795.7
 Nup133
nucleoporin 133
chr18_+_36559972 0.090 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr11_+_97315716 0.085 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chr19_-_40588338 0.064 ENSMUST00000176939.1
 Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr6_+_29348069 0.045 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
 Calu


calumenin


chr6_-_87672142 0.041 ENSMUST00000032130.2
ENSMUST00000065997.2
 Aplf

aprataxin and PNKP like factor

chr1_+_95313607 0.017 ENSMUST00000059975.6
 Fam174a
family with sequence similarity 174, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.7 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.5 1.6 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.4 1.1 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.3 2.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.3 2.7 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 0.8 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.2 1.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.2 0.6 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 0.9 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 1.9 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.4 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.1 0.5 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 2.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 1.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.8 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 0.5 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.2 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661) regulation of microtubule motor activity(GO:2000574)
0.0 0.9 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.9 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 1.4 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.2 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.6 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 0.2 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 1.8 GO:0051028 mRNA transport(GO:0051028)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515) chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.3 GO:2000811 negative regulation of anoikis(GO:2000811)
0.0 0.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.2 GO:0060416 response to growth hormone(GO:0060416)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.6 4.7 GO:0098536 deuterosome(GO:0098536)
0.1 0.6 GO:0071942 XPC complex(GO:0071942)
0.1 1.2 GO:0061617 MICOS complex(GO:0061617)
0.1 1.6 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.9 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0044292 dendrite terminus(GO:0044292)
0.0 1.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.5 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.4 1.8 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 0.6 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 2.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0032564 dATP binding(GO:0032564)
0.1 1.6 GO:0043236 laminin binding(GO:0043236)
0.0 2.7 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.4 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.0 0.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.9 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.2 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.3 GO:0071949 FAD binding(GO:0071949)
0.0 0.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)