Motif ID: Gsc2_Dmbx1

Z-value: 0.654

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_115939928-0.077.4e-01Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_137766474 3.680 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr14_-_118052235 2.758 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr7_-_133015248 2.694 ENSMUST00000169570.1
 Ctbp2
C-terminal binding protein 2
chr5_+_77265454 2.520 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr17_+_35861318 1.960 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr2_+_164562579 1.936 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr11_-_52282564 1.876 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr16_-_46010212 1.738 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_-_22149270 1.659 ENSMUST00000179054.1
ENSMUST00000069372.6
 E030030I06Rik

RIKEN cDNA E030030I06 gene

chr17_+_35861343 1.609 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr4_-_141053660 1.594 ENSMUST00000040222.7
 Crocc
ciliary rootlet coiled-coil, rootletin
chr2_+_91259822 1.592 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr8_+_13405080 1.467 ENSMUST00000033827.7
 Grk1
G protein-coupled receptor kinase 1
chr6_+_136954521 1.338 ENSMUST00000137768.1
 Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr1_-_44218952 1.325 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr9_+_50617516 1.316 ENSMUST00000141366.1
 Pih1d2
PIH1 domain containing 2
chr4_+_154960915 1.229 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_-_68973840 1.214 ENSMUST00000038644.4
 Rangrf
RAN guanine nucleotide release factor
chr1_+_44551483 1.189 ENSMUST00000074525.3
 Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr19_-_12765447 1.147 ENSMUST00000112933.1
 Cntf
ciliary neurotrophic factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0046677 response to antibiotic(GO:0046677)
0.3 3.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.5 2.8 GO:0006570 tyrosine metabolic process(GO:0006570)
0.6 2.5 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 2.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.7 2.1 GO:0032053 ciliary basal body organization(GO:0032053)
0.7 2.1 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.2 1.9 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 1.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.5 1.5 GO:0016056 photoreceptor cell morphogenesis(GO:0008594) rhodopsin mediated signaling pathway(GO:0016056) post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 1.3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.3 1.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 1.2 GO:2000010 positive regulation of protein localization to cell surface(GO:2000010)
0.3 1.1 GO:0046533 negative regulation of photoreceptor cell differentiation(GO:0046533)
0.3 1.0 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.0 1.0 GO:0007601 visual perception(GO:0007601)
0.2 0.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.8 GO:0030576 Cajal body organization(GO:0030576)
0.2 0.8 GO:0001561 fatty acid alpha-oxidation(GO:0001561)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 3.6 GO:0005652 nuclear lamina(GO:0005652)
0.2 3.1 GO:0097470 ribbon synapse(GO:0097470)
0.1 2.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 2.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.4 1.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.8 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.4 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.3 GO:0005921 gap junction(GO:0005921)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 3.1 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.2 2.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 2.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 2.1 GO:0030332 cyclin binding(GO:0030332)
0.0 2.1 GO:0019894 kinesin binding(GO:0019894)
0.3 2.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 2.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.5 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 1.3 GO:0030553 cGMP binding(GO:0030553)
0.1 1.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.3 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.1 1.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.3 0.8 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.1 0.8 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)