Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.627

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx1mm10_v2_chr5_+_147188678_147188696-0.517.9e-03Click!
Alx1mm10_v2_chr10_-_103028771_103028782-0.058.0e-01Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_20737306 5.394 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr3_-_79841729 2.626 ENSMUST00000168038.1
 Tmem144
transmembrane protein 144
chr5_-_84417359 2.021 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr8_+_23411490 1.936 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr2_+_116067213 1.924 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chrX_-_60893430 1.827 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr9_+_118478182 1.395 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 1.379 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_-_116067391 1.353 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr7_-_116198487 1.236 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chrX_-_74246534 1.172 ENSMUST00000101454.2
ENSMUST00000033699.6
 Flna

filamin, alpha

chr9_+_35423582 1.120 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr3_-_88410295 1.098 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr16_-_26989974 1.083 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chrX_-_102157065 1.070 ENSMUST00000056904.2
 Ercc6l
excision repair cross-complementing rodent repair deficiency complementation group 6 like
chr6_-_147264124 1.054 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr8_-_61902669 1.032 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chrX_+_56454871 1.021 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr7_+_29071597 0.998 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr7_+_103550368 0.968 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.3 2.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.9 2.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.6 1.9 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.8 GO:0007530 sex determination(GO:0007530)
0.1 1.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.2 1.5 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.4 1.2 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 1.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 1.2 GO:0007608 sensory perception of smell(GO:0007608)
0.1 1.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.1 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.0 1.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.0 GO:0032782 bile acid secretion(GO:0032782)
0.1 1.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.0 GO:0097352 autophagosome maturation(GO:0097352)
0.3 0.9 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.2 0.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 1.5 GO:0031523 Myb complex(GO:0031523)
0.3 1.2 GO:0060187 cell pole(GO:0060187)
0.1 1.2 GO:0005915 zonula adherens(GO:0005915)
0.0 1.2 GO:0070469 respiratory chain(GO:0070469)
0.2 1.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.1 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.0 GO:0043205 fibril(GO:0043205)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 1.0 GO:0000786 nucleosome(GO:0000786)
0.2 0.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0001940 male pronucleus(GO:0001940)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 2.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 1.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 1.2 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 1.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.8 GO:0015265 urea channel activity(GO:0015265)
0.1 0.8 GO:0000150 recombinase activity(GO:0000150)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)