Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.683

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.681.4e-04Click!
Vax1mm10_v2_chr19_-_59170978_591709780.423.1e-02Click!


Activity profile for motif Gsx2_Hoxd3_Vax1.

activity profile for motif Gsx2_Hoxd3_Vax1


Sorted Z-values histogram for motif Gsx2_Hoxd3_Vax1

Sorted Z-values for motif Gsx2_Hoxd3_Vax1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 4.449 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr9_+_119063429 4.111 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_+_109917639 3.781 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_-_168767136 2.950 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr19_+_55895508 2.601 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr3_+_55782500 2.579 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr2_-_168767029 2.170 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr4_+_8690399 2.036 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr18_+_56432116 1.921 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr6_-_23248264 1.748 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_+_25773985 1.621 ENSMUST00000125667.1
 Myo10
myosin X
chr13_-_53473074 1.502 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr3_+_159839729 1.400 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr12_-_55014329 1.292 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr12_+_38780284 1.284 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 1.241 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr11_+_59306920 1.191 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr17_-_70853482 1.130 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr5_+_138187485 1.129 ENSMUST00000110934.2
 Cnpy4
canopy 4 homolog (zebrafish)
chr2_-_28916412 1.088 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.1 4.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 3.9 GO:0051693 actin filament capping(GO:0051693)
1.3 3.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 2.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.7 2.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.7 2.0 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0 1.9 GO:0030901 midbrain development(GO:0030901)
0.3 1.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.6 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.0 1.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 1.4 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 1.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 1.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 1.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 1.0 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.3 0.9 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 0.8 GO:0015819 lysine transport(GO:0015819)
0.2 0.7 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.7 GO:0006348 chromatin silencing at telomere(GO:0006348)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0000792 heterochromatin(GO:0000792)
0.0 4.4 GO:0030426 growth cone(GO:0030426)
0.3 2.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.6 GO:0016459 myosin complex(GO:0016459)
0.0 1.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 1.3 GO:0008623 CHRAC(GO:0008623)
0.0 1.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 1.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.9 GO:0016600 flotillin complex(GO:0016600)
0.0 0.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.6 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.4 GO:0070695 FHF complex(GO:0070695)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 3.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 3.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 2.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.6 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 1.6 GO:0030507 spectrin binding(GO:0030507)
0.1 1.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.1 1.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.1 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.9 GO:0031432 titin binding(GO:0031432)
0.0 0.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.8 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.7 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)