Motif ID: Gtf2i_Gtf2f1

Z-value: 2.568

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314678_134314760-0.636.3e-04Click!
Gtf2f1mm10_v2_chr17_-_57011271_57011326-0.394.9e-02Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 36.877 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr5_-_44799643 15.309 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr7_+_44310213 15.204 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr1_-_56971762 14.866 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr14_-_55116935 14.111 ENSMUST00000022819.5
 Jph4
junctophilin 4
chrX_-_104201126 11.556 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr19_+_6497772 10.106 ENSMUST00000113458.1
ENSMUST00000113459.1
 Nrxn2

neurexin II

chr13_+_42709482 9.837 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr7_-_120202104 9.797 ENSMUST00000033198.5
 Crym
crystallin, mu
chr7_-_78578308 9.740 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr9_+_40686002 9.666 ENSMUST00000034522.7
 Clmp
CXADR-like membrane protein
chr5_-_120711927 9.640 ENSMUST00000031607.6
 Dtx1
deltex 1 homolog (Drosophila)
chr1_-_72536930 9.442 ENSMUST00000047786.5
 March4
membrane-associated ring finger (C3HC4) 4
chr10_+_13966268 9.395 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr15_+_83791939 9.162 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr12_+_105336922 9.029 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr16_-_42340595 8.839 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr16_-_74411292 8.801 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr7_-_126949499 8.796 ENSMUST00000106339.1
ENSMUST00000052937.5
 Asphd1

aspartate beta-hydroxylase domain containing 1

chr7_+_46397648 8.783 ENSMUST00000160433.1
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 595 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 36.9 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
2.2 34.6 GO:2000821 regulation of grooming behavior(GO:2000821)
2.2 33.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 28.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
4.0 24.1 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.7 20.8 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
6.7 20.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
2.7 18.8 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
1.5 18.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
1.3 16.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6 16.0 GO:0035640 exploration behavior(GO:0035640)
1.0 15.6 GO:0071625 vocalization behavior(GO:0071625)
5.1 15.4 GO:0046959 habituation(GO:0046959)
4.8 14.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
2.8 13.9 GO:0070327 thyroid hormone transport(GO:0070327)
0.8 13.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.6 13.7 GO:0048266 behavioral response to pain(GO:0048266)
0.8 13.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.5 13.4 GO:0007616 long-term memory(GO:0007616)
0.2 12.9 GO:0007612 learning(GO:0007612)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 70.4 GO:0031224 intrinsic component of membrane(GO:0031224)
0.3 67.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.9 50.7 GO:0042734 presynaptic membrane(GO:0042734)
0.3 48.1 GO:0070382 exocytic vesicle(GO:0070382)
2.0 41.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.0 36.6 GO:0055038 recycling endosome membrane(GO:0055038)
1.6 27.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 26.9 GO:0005773 vacuole(GO:0005773)
1.6 26.1 GO:0032279 asymmetric synapse(GO:0032279)
4.9 24.4 GO:0030314 junctional membrane complex(GO:0030314)
1.0 24.2 GO:0030673 axolemma(GO:0030673)
0.1 24.1 GO:0045202 synapse(GO:0045202)
0.4 24.0 GO:0034705 potassium channel complex(GO:0034705)
0.3 22.2 GO:0043204 perikaryon(GO:0043204)
0.2 19.6 GO:0005905 clathrin-coated pit(GO:0005905)
1.9 18.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.6 18.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 17.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 16.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
3.2 15.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 369 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 50.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 44.3 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.2 29.5 GO:0017124 SH3 domain binding(GO:0017124)
0.7 22.9 GO:0070412 R-SMAD binding(GO:0070412)
0.5 20.8 GO:0045296 cadherin binding(GO:0045296)
2.2 20.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.8 19.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 19.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.9 18.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
2.6 17.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.7 17.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
2.2 17.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.3 16.5 GO:0035254 glutamate receptor binding(GO:0035254)
4.1 16.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
2.6 15.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.9 15.5 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.4 15.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.8 15.3 GO:0034185 apolipoprotein binding(GO:0034185)
1.9 15.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 14.9 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)