Motif ID: Hand1

Z-value: 1.509


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_30445508 8.061 ENSMUST00000006828.7
 Aplp1
amyloid beta (A4) precursor-like protein 1
chr19_-_59076069 7.754 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr15_+_81936911 6.637 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr4_-_138396438 6.205 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr13_-_37049203 5.109 ENSMUST00000037491.8
 F13a1
coagulation factor XIII, A1 subunit
chr15_+_92051153 4.820 ENSMUST00000169825.1
 Cntn1
contactin 1
chr11_+_57011945 4.421 ENSMUST00000094179.4
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr8_+_84723003 4.333 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr11_+_57011798 4.096 ENSMUST00000036315.9
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr19_-_4698315 4.068 ENSMUST00000096325.3
 Gm960
predicted gene 960
chr9_-_51077064 4.026 ENSMUST00000098782.3
 Layn
layilin
chr11_-_81968415 3.932 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr2_+_118663235 3.840 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_82035569 3.818 ENSMUST00000000193.5
 Ccl2
chemokine (C-C motif) ligand 2
chr4_+_130913264 3.798 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr15_+_81936753 3.787 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_80097866 3.759 ENSMUST00000143928.1
 Syngr1
synaptogyrin 1
chr8_-_109251698 3.756 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr2_-_168741752 3.714 ENSMUST00000029060.4
 Atp9a
ATPase, class II, type 9A
chr14_-_73385225 3.581 ENSMUST00000022704.7
 Itm2b
integral membrane protein 2B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 12.7 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.3 8.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
2.7 8.1 GO:0071873 response to norepinephrine(GO:0071873)
0.5 7.8 GO:0018149 peptide cross-linking(GO:0018149)
0.3 7.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 7.0 GO:0006397 mRNA processing(GO:0006397)
2.0 5.9 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 5.9 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.5 5.5 GO:1900112 regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 5.4 GO:0007613 memory(GO:0007613)
0.8 5.0 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
1.0 4.8 GO:2001025 positive regulation of response to drug(GO:2001025)
0.0 4.7 GO:0006906 vesicle fusion(GO:0006906)
0.3 4.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.4 4.1 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 4.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.0 4.0 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
1.3 3.9 GO:0050915 sensory perception of sour taste(GO:0050915)
1.0 3.8 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.4 3.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 10.0 GO:0044308 axonal spine(GO:0044308)
0.2 8.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 7.8 GO:0043198 dendritic shaft(GO:0043198)
0.1 7.0 GO:0072562 blood microparticle(GO:0072562)
1.1 6.3 GO:1990635 proximal dendrite(GO:1990635)
0.1 5.6 GO:0043195 terminal bouton(GO:0043195)
0.2 5.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 5.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 5.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.0 5.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.7 5.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 4.7 GO:0031985 Golgi cisterna(GO:0031985)
0.0 4.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 4.2 GO:0048786 presynaptic active zone(GO:0048786)
0.2 4.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 4.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.9 GO:0043209 myelin sheath(GO:0043209)
1.3 3.8 GO:0044299 C-fiber(GO:0044299)
0.5 3.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 3.8 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.0 8.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 7.5 GO:0035254 glutamate receptor binding(GO:0035254)
1.0 5.9 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 5.9 GO:0030276 clathrin binding(GO:0030276)
0.3 5.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 5.3 GO:0005516 calmodulin binding(GO:0005516)
1.3 5.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.8 5.1 GO:0070699 type II activin receptor binding(GO:0070699)
1.2 5.0 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.3 5.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 4.9 GO:0001948 glycoprotein binding(GO:0001948)
0.2 4.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 4.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 4.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 4.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 3.9 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
1.0 3.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.8 3.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.3 3.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)