Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 2.679

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six5mm10_v2_chr7_+_19094594_190946330.331.0e-01Click!
Zfp143mm10_v2_chr7_+_110061702_1100617320.321.1e-01Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.281.7e-01Click!
Smarcc2mm10_v2_chr10_+_128459236_128459248-0.067.8e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_44997535 3.700 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr14_+_64950037 3.481 ENSMUST00000043914.5
 Ints9
integrator complex subunit 9
chr4_+_116708687 3.342 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr2_+_118598209 3.244 ENSMUST00000038341.7
 Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr7_-_44997221 3.155 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr4_-_116708312 3.054 ENSMUST00000030453.4
 Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr4_+_116708571 3.001 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr4_+_116708624 2.916 ENSMUST00000106463.1
 Ccdc163
coiled-coil domain containing 163
chr11_+_69995777 2.752 ENSMUST00000018716.3
 Phf23
PHD finger protein 23
chr11_+_69995874 2.735 ENSMUST00000101526.2
 Phf23
PHD finger protein 23
chr17_+_80127447 2.567 ENSMUST00000039205.4
 Galm
galactose mutarotase
chr4_+_116708467 2.422 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr5_-_149636331 2.369 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1



chr19_-_10203880 2.283 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
 Fen1



flap structure specific endonuclease 1



chr7_+_44997648 2.083 ENSMUST00000003284.8
ENSMUST00000107835.1
 Irf3

interferon regulatory factor 3

chr7_+_12897800 1.949 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr5_+_33658123 1.842 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr1_+_151428612 1.828 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr9_+_83548309 1.796 ENSMUST00000113215.3
 Sh3bgrl2
SH3 domain binding glutamic acid-rich protein like 2
chr6_+_124829540 1.768 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 342 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.1 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 6.9 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375)
0.0 5.7 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 5.6 GO:0006412 translation(GO:0006412)
1.8 5.5 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.3 4.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.6 4.3 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.0 4.2 GO:0007067 mitotic nuclear division(GO:0007067)
0.2 3.6 GO:0016180 snRNA processing(GO:0016180)
0.2 3.5 GO:0030953 astral microtubule organization(GO:0030953)
0.6 3.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 3.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 3.0 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.2 3.0 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.6 2.9 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.5 2.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.3 2.6 GO:0006012 galactose metabolic process(GO:0006012)
0.2 2.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.6 2.4 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.2 2.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0005730 nucleolus(GO:0005730)
0.0 5.8 GO:0005840 ribosome(GO:0005840)
0.0 5.4 GO:0005813 centrosome(GO:0005813)
0.3 3.9 GO:0032039 integrator complex(GO:0032039)
0.3 3.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 3.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.5 GO:0005643 nuclear pore(GO:0005643)
0.5 3.4 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.4 3.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 3.0 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 3.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 3.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 2.8 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 2.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.8 2.4 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 2.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.3 2.3 GO:0005818 aster(GO:0005818)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 238 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 6.0 GO:0002039 p53 binding(GO:0002039)
0.1 5.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 4.6 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.5 3.6 GO:0048256 flap endonuclease activity(GO:0048256)
0.5 3.4 GO:0031419 cobalamin binding(GO:0031419)
0.5 2.8 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.1 2.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 2.7 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.2 2.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 2.5 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 2.5 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.5 2.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.3 2.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 2.3 GO:0001671 ATPase activator activity(GO:0001671)
0.4 2.2 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 2.2 GO:0000150 recombinase activity(GO:0000150)
0.2 2.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 2.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)