Motif ID: Hdx

Z-value: 5.537


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.106.3e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3017408 111.946 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 100.046 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3005125 91.001 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3023547 87.444 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3034599 79.470 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3000922 77.015 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 71.785 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3025417 68.035 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr14_-_19418930 63.355 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 57.111 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 52.713 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3036877 48.231 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3037111 44.811 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3013140 40.795 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr2_-_98667264 29.502 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr6_-_23248264 14.703 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_+_24327415 7.897 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr15_+_10177623 4.619 ENSMUST00000124470.1
 Prlr
prolactin receptor
chr16_-_26989974 4.297 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chrX_-_21089229 4.223 ENSMUST00000040667.6
 Zfp300
zinc finger protein 300
chr3_-_154330543 3.829 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr11_+_82101836 3.777 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chrX_+_169879596 3.559 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr5_-_27501362 3.542 ENSMUST00000155721.1
ENSMUST00000053257.3
 Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

chr16_+_14705832 3.161 ENSMUST00000023356.6
 Snai2
snail homolog 2 (Drosophila)
chrX_-_143827391 2.910 ENSMUST00000087316.5
 Capn6
calpain 6
chr13_-_113663670 2.554 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr5_+_90794530 2.419 ENSMUST00000031322.6
 Cxcl15
chemokine (C-X-C motif) ligand 15
chr12_-_27160311 2.390 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr19_+_12460749 2.054 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr7_+_13398115 2.046 ENSMUST00000005791.7
 Cabp5
calcium binding protein 5
chr9_+_53771499 1.988 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr17_+_17402672 1.853 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr11_+_98446826 1.766 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chr8_+_66697404 1.752 ENSMUST00000039303.5
 Npy1r
neuropeptide Y receptor Y1
chr7_+_46847128 1.537 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr3_-_54915867 1.537 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr13_-_67729109 1.484 ENSMUST00000073157.6
 Zfp71-rs1
zinc finger protein 71, related sequence
chr11_-_28584260 1.407 ENSMUST00000093253.3
ENSMUST00000109502.2
ENSMUST00000042534.8
 Ccdc85a


coiled-coil domain containing 85A


chr12_-_87775755 1.322 ENSMUST00000164517.2
 Gm21319
predicted gene, 21319
chr14_-_68655804 1.308 ENSMUST00000111072.1
ENSMUST00000022642.5
 Adam28

a disintegrin and metallopeptidase domain 28

chr10_+_85928491 1.298 ENSMUST00000170396.1
 Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr9_-_39604124 1.292 ENSMUST00000042485.4
ENSMUST00000141370.1
 AW551984

expressed sequence AW551984

chr2_+_116900152 1.262 ENSMUST00000126467.1
ENSMUST00000128305.1
ENSMUST00000155323.1
 D330050G23Rik


RIKEN cDNA D330050G23 gene


chr14_+_115092244 1.258 ENSMUST00000176912.1
ENSMUST00000175665.1
 Gpc5

glypican 5

chr4_-_115133977 1.082 ENSMUST00000051400.7
 Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr1_-_54194048 1.080 ENSMUST00000120904.1
 Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr8_+_84415348 1.078 ENSMUST00000121390.1
ENSMUST00000122053.1
 Cacna1a

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

chr17_-_34743849 1.076 ENSMUST00000069507.8
 C4b
complement component 4B (Chido blood group)
chr11_-_45955465 1.050 ENSMUST00000011398.6
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr12_-_23780265 0.997 ENSMUST00000072014.4
 Gm10330
predicted gene 10330
chr2_-_72986716 0.993 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr9_+_45055166 0.948 ENSMUST00000114664.1
ENSMUST00000093856.3
 Mpzl3

myelin protein zero-like 3

chr6_+_30568367 0.939 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chrX_+_143518576 0.932 ENSMUST00000033640.7
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr10_-_80918212 0.896 ENSMUST00000057623.7
ENSMUST00000179022.1
 Lmnb2

lamin B2

chr10_+_7667503 0.839 ENSMUST00000040135.8
 Nup43
nucleoporin 43
chr11_-_45955183 0.824 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr4_+_124880899 0.664 ENSMUST00000059343.6
 Epha10
Eph receptor A10
chr13_+_43370710 0.624 ENSMUST00000066804.4
 Sirt5
sirtuin 5
chr4_-_133753611 0.624 ENSMUST00000145664.2
ENSMUST00000105897.3
 Arid1a

AT rich interactive domain 1A (SWI-like)

chr15_-_56694525 0.582 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr11_+_95666957 0.571 ENSMUST00000125172.1
ENSMUST00000036374.5
 Phb

prohibitin

chr9_-_39603635 0.545 ENSMUST00000119722.1
 AW551984
expressed sequence AW551984
chr3_-_20242173 0.532 ENSMUST00000001921.1
 Cpa3
carboxypeptidase A3, mast cell
chr3_-_129755305 0.528 ENSMUST00000029653.2
 Egf
epidermal growth factor
chr1_-_140183283 0.525 ENSMUST00000111977.1
 Cfh
complement component factor h
chr18_-_47333311 0.525 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr4_-_129640691 0.474 ENSMUST00000084264.5
 Txlna
taxilin alpha
chr5_-_129879038 0.471 ENSMUST00000026617.6
 Phkg1
phosphorylase kinase gamma 1
chrX_+_143518671 0.383 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr14_+_70774304 0.295 ENSMUST00000022698.7
 Dok2
docking protein 2
chr19_+_8953826 0.282 ENSMUST00000096239.5
 Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr4_+_89137122 0.279 ENSMUST00000058030.7
 Mtap
methylthioadenosine phosphorylase
chr7_-_44257378 0.278 ENSMUST00000107945.1
ENSMUST00000118216.1
 Acpt

acid phosphatase, testicular

chr5_+_30013141 0.276 ENSMUST00000026845.7
 Il6
interleukin 6
chr1_+_87327044 0.266 ENSMUST00000173173.1
 Gigyf2
GRB10 interacting GYF protein 2
chr13_+_60602182 0.234 ENSMUST00000044083.7
 Dapk1
death associated protein kinase 1
chr16_+_37539883 0.228 ENSMUST00000023524.6
 Rabl3
RAB, member of RAS oncogene family-like 3
chrX_+_164419782 0.207 ENSMUST00000033754.7
 Piga
phosphatidylinositol glycan anchor biosynthesis, class A
chrX_+_56779699 0.202 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
 Fhl1


four and a half LIM domains 1


chr4_-_129640959 0.190 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
 Txlna


taxilin alpha


chr15_-_80083374 0.189 ENSMUST00000081650.7
 Rpl3
ribosomal protein L3
chr1_-_140183404 0.172 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chrX_+_56779437 0.171 ENSMUST00000114773.3
 Fhl1
four and a half LIM domains 1
chr11_-_76509419 0.147 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr2_+_3118335 0.136 ENSMUST00000115099.2
 Fam171a1
family with sequence similarity 171, member A1
chr4_+_3938904 0.097 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
 Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr6_-_131313827 0.093 ENSMUST00000049150.1
 Styk1
serine/threonine/tyrosine kinase 1
chr13_+_60601921 0.072 ENSMUST00000077453.5
 Dapk1
death associated protein kinase 1
chr4_-_43031429 0.051 ENSMUST00000136326.1
 Stoml2
stomatin (Epb7.2)-like 2
chr1_+_87327008 0.046 ENSMUST00000172794.1
ENSMUST00000164992.2
 Gigyf2

GRB10 interacting GYF protein 2

chr5_+_100196611 0.036 ENSMUST00000066813.1
 Gm9932
predicted gene 9932
chr1_+_87326997 0.005 ENSMUST00000027475.8
 Gigyf2
GRB10 interacting GYF protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
2.5 14.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.3 3.8 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
1.1 3.2 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.9 4.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) prolactin signaling pathway(GO:0038161)
0.4 1.1 GO:0061526 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) musculoskeletal movement, spinal reflex action(GO:0050883) acetylcholine secretion(GO:0061526)
0.3 1.5 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.3 1.8 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.2 1.1 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.2 1.8 GO:0030432 peristalsis(GO:0030432)
0.1 4.3 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:0002922 positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847)
0.1 2.2 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 0.6 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 0.3 GO:0002295 T-helper cell lineage commitment(GO:0002295)
0.1 3.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.9 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.5 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 1.8 GO:0034063 stress granule assembly(GO:0034063)
0.1 3.8 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.3 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.1 1.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.3 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 1.1 GO:0006956 complement activation(GO:0006956)
0.0 0.6 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 676.4 GO:0008150 biological_process(GO:0008150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.9 GO:0005638 lamin filament(GO:0005638)
0.1 1.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.6 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 1.1 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 2.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 733.7 GO:0005575 cellular_component(GO:0005575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.9 3.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.4 1.3 GO:0001851 complement component C3b binding(GO:0001851)
0.4 1.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.3 1.8 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.2 1.9 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.2 2.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 1.1 GO:0070330 aromatase activity(GO:0070330)
0.2 1.1 GO:0001849 complement component C1q binding(GO:0001849)
0.2 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 2.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 4.6 GO:0017046 peptide hormone binding(GO:0017046)
0.1 0.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 1.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 12.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 695.4 GO:0003674 molecular_function(GO:0003674)