Motif ID: Hes1

Z-value: 1.630


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.751.1e-05Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 16.930 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 16.600 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr4_+_65124174 5.953 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr17_-_25797032 5.537 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr19_+_60144682 5.131 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_+_153652943 4.825 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr12_+_110279228 4.392 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr6_+_120666388 4.298 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr11_-_89302545 4.179 ENSMUST00000061728.3
 Nog
noggin
chr1_-_189688074 3.979 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr19_-_24555819 3.961 ENSMUST00000112673.2
ENSMUST00000025800.8
 Pip5k1b

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

chr9_-_75409951 3.921 ENSMUST00000049355.10
 Mapk6
mitogen-activated protein kinase 6
chr1_-_166309585 3.891 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr4_+_116877376 3.532 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5
chr1_-_175692624 3.425 ENSMUST00000027809.7
 Opn3
opsin 3
chr12_+_116077720 3.294 ENSMUST00000011315.3
 Vipr2
vasoactive intestinal peptide receptor 2
chr7_+_79660196 3.238 ENSMUST00000035977.7
 Ticrr
TOPBP1-interacting checkpoint and replication regulator
chr13_-_81710937 3.217 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr8_+_71406003 3.173 ENSMUST00000119976.1
ENSMUST00000120725.1
 Ankle1

ankyrin repeat and LEM domain containing 1

chr8_+_119446719 3.133 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 33.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 7.8 GO:0008380 RNA splicing(GO:0008380)
1.5 6.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 5.0 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.4 4.8 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.6 4.5 GO:0001842 neural fold formation(GO:0001842)
0.7 4.4 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.7 4.4 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
1.0 4.2 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 4.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 4.1 GO:0051384 response to glucocorticoid(GO:0051384)
0.1 4.0 GO:0051310 metaphase plate congression(GO:0051310)
0.4 3.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 3.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.9 3.6 GO:0003360 brainstem development(GO:0003360)
1.1 3.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.5 3.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.4 3.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174) mitotic DNA replication checkpoint(GO:0033314)
1.0 3.1 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.1 3.1 GO:0009409 response to cold(GO:0009409)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.2 GO:0005615 extracellular space(GO:0005615)
0.0 8.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 7.4 GO:0030139 endocytic vesicle(GO:0030139)
0.1 4.8 GO:0032809 neuronal cell body membrane(GO:0032809)
1.1 4.3 GO:0090537 CERF complex(GO:0090537)
0.4 4.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 4.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 3.9 GO:0032156 septin cytoskeleton(GO:0032156)
0.3 3.8 GO:0035686 sperm fibrous sheath(GO:0035686)
1.2 3.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 3.6 GO:0005681 spliceosomal complex(GO:0005681)
0.2 3.3 GO:0016580 Sin3 complex(GO:0016580)
0.1 3.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 3.1 GO:0072372 primary cilium(GO:0072372)
0.1 3.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4 2.5 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 2.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.2 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 33.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 6.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.0 6.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 5.4 GO:0070888 E-box binding(GO:0070888)
0.0 5.2 GO:0042393 histone binding(GO:0042393)
0.1 4.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.2 GO:0004707 MAP kinase activity(GO:0004707)
0.1 4.2 GO:0019955 cytokine binding(GO:0019955)
0.1 4.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.5 4.0 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 4.0 GO:0045502 dynein binding(GO:0045502)
0.8 3.9 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.6 3.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.6 3.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
1.1 3.4 GO:0009881 photoreceptor activity(GO:0009881)
1.1 3.4 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.8 3.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 3.0 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 2.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)