Motif ID: Hes5_Hes7

Z-value: 1.421

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.572.4e-03Click!
Hes7mm10_v2_chr11_+_69120404_69120404-0.404.3e-02Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026732 25.317 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026237 24.822 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr10_-_87493651 8.020 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr12_-_56536895 6.793 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr12_+_109459843 6.006 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_4755327 5.232 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr2_+_163203072 5.162 ENSMUST00000109428.2
 Tox2
TOX high mobility group box family member 2
chr5_+_128601106 4.711 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr9_-_36726374 4.208 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr5_+_28165690 4.160 ENSMUST00000036177.7
 En2
engrailed 2
chr2_-_92370999 3.744 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr8_-_87804411 3.411 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423
chr13_+_108316332 3.273 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr13_+_108316395 3.243 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr8_+_119446719 3.097 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr13_+_51846673 3.026 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr9_+_64121501 2.769 ENSMUST00000118215.1
 Lctl
lactase-like
chr2_-_92371039 2.632 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chr2_-_92370968 2.546 ENSMUST00000176774.1
 Gyltl1b
glycosyltransferase-like 1B
chr4_+_137913471 2.525 ENSMUST00000151110.1
 Ece1
endothelin converting enzyme 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 50.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.6 8.9 GO:0035269 protein O-linked mannosylation(GO:0035269)
2.7 8.0 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
2.3 6.8 GO:0021759 globus pallidus development(GO:0021759)
0.1 6.5 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.2 6.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 4.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.6 4.7 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.6 4.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.7 4.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.3 4.2 GO:1990403 embryonic brain development(GO:1990403)
0.1 3.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.3 3.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 3.0 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.9 2.8 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.8 2.5 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.4 2.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 2.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 2.4 GO:0008340 determination of adult lifespan(GO:0008340)
0.5 2.2 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 40.7 GO:0005829 cytosol(GO:0005829)
0.1 8.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 6.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 4.2 GO:0005657 replication fork(GO:0005657)
0.1 3.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 3.3 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 2.8 GO:0005903 brush border(GO:0005903)
0.5 2.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 2.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.7 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.5 GO:0005652 nuclear lamina(GO:0005652)
0.2 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0001650 fibrillar center(GO:0001650)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 50.1 GO:0001784 phosphotyrosine binding(GO:0001784)
1.8 8.9 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.2 8.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.6 6.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 4.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 4.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 4.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
1.4 4.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.3 2.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 2.2 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.6 1.9 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 1.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 1.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.3 1.3 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.1 1.3 GO:0034185 apolipoprotein binding(GO:0034185)