Motif ID: Hey1_Myc_Mxi1

Z-value: 0.951

Transcription factors associated with Hey1_Myc_Mxi1:

Gene SymbolEntrez IDGene Name
Hey1 ENSMUSG00000040289.3 Hey1
Mxi1 ENSMUSG00000025025.7 Mxi1
Myc ENSMUSG00000022346.8 Myc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mxi1mm10_v2_chr19_+_53310495_53310552-0.731.9e-05Click!
Hey1mm10_v2_chr3_-_8667033_86670460.367.3e-02Click!
Mycmm10_v2_chr15_+_61987034_61987059-0.348.9e-02Click!


Activity profile for motif Hey1_Myc_Mxi1.

activity profile for motif Hey1_Myc_Mxi1


Sorted Z-values histogram for motif Hey1_Myc_Mxi1

Sorted Z-values for motif Hey1_Myc_Mxi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey1_Myc_Mxi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_95882193 5.126 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr19_+_56874249 3.217 ENSMUST00000026068.7
 Vwa2
von Willebrand factor A domain containing 2
chr3_-_95882031 3.062 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr9_-_43239816 2.862 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr3_-_95882232 2.787 ENSMUST00000161866.1
 Gm129
predicted gene 129
chr5_-_137314175 2.541 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr10_+_127063527 2.436 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr1_-_17097839 2.268 ENSMUST00000038382.4
 Jph1
junctophilin 1
chr14_-_20181773 2.233 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr18_+_35553401 2.132 ENSMUST00000181664.1
 Snhg4
small nucleolar RNA host gene 4 (non-protein coding)
chr10_+_127063599 2.126 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr2_-_92370999 2.002 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr5_-_45639501 1.838 ENSMUST00000016023.7
 Fam184b
family with sequence similarity 184, member B
chr3_+_104638658 1.827 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr15_-_43170809 1.759 ENSMUST00000063492.6
 Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr7_-_126799163 1.741 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr9_-_114781986 1.701 ENSMUST00000035009.8
ENSMUST00000084867.7
 Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr12_+_17544873 1.675 ENSMUST00000171737.1
 Odc1
ornithine decarboxylase, structural 1
chr7_+_141476374 1.638 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr2_-_92371039 1.632 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 440 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 GO:0035269 protein O-linked mannosylation(GO:0035269)
1.1 4.6 GO:0010288 response to lead ion(GO:0010288)
0.6 4.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.5 4.1 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 4.0 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.4 3.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 3.7 GO:0007601 visual perception(GO:0007601)
1.1 3.2 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.8 3.1 GO:0060266 positive regulation of respiratory burst involved in inflammatory response(GO:0060265) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)
0.6 3.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.5 3.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.3 3.0 GO:0006228 UTP biosynthetic process(GO:0006228)
0.6 2.9 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.5 2.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 2.9 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 2.7 GO:0006405 RNA export from nucleus(GO:0006405)
0.9 2.6 GO:0090194 negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194)
0.1 2.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 2.5 GO:0006414 translational elongation(GO:0006414)
0.3 2.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 4.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 4.4 GO:0005604 basement membrane(GO:0005604)
0.0 4.1 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.3 3.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 3.7 GO:0034399 nuclear periphery(GO:0034399)
0.1 3.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 3.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 3.1 GO:0005642 annulate lamellae(GO:0005642)
0.2 3.1 GO:0043196 varicosity(GO:0043196)
0.3 2.8 GO:0031415 NatA complex(GO:0031415)
0.1 2.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 2.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 2.1 GO:0016604 nuclear body(GO:0016604)
0.4 2.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 2.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 1.8 GO:0034719 SMN-Sm protein complex(GO:0034719)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 299 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 5.1 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.3 4.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 4.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 4.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 4.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 3.9 GO:0016428 tRNA (cytosine) methyltransferase activity(GO:0016427) tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.1 3.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.5 3.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 3.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.6 3.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.2 3.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 3.1 GO:0030332 cyclin binding(GO:0030332)
0.1 2.9 GO:0045182 translation regulator activity(GO:0045182)
0.0 2.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 2.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.3 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 2.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 2.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 2.2 GO:0022841 potassium ion leak channel activity(GO:0022841)