Motif ID: Hey2

Z-value: 0.713


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_30842801-0.491.0e-02Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 173 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_120348513 2.311 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr5_+_141241490 2.219 ENSMUST00000085774.4
 Sdk1
sidekick homolog 1 (chicken)
chr11_+_120721452 2.193 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr6_-_88875035 2.140 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr11_+_120721543 2.130 ENSMUST00000142229.1
 Rac3
RAS-related C3 botulinum substrate 3
chr8_-_70700070 2.093 ENSMUST00000116172.1
 Gm11175
predicted gene 11175
chr16_-_18621366 2.003 ENSMUST00000051160.2
 Gp1bb
glycoprotein Ib, beta polypeptide
chr18_-_61911783 1.997 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr13_-_14523178 1.932 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr1_+_120340569 1.880 ENSMUST00000037286.8
 C1ql2
complement component 1, q subcomponent-like 2
chr19_+_6418731 1.773 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
 Nrxn2


neurexin II


chr2_-_168741898 1.693 ENSMUST00000109176.1
ENSMUST00000178504.1
 Atp9a

ATPase, class II, type 9A

chr6_+_54816906 1.660 ENSMUST00000079869.6
 Znrf2
zinc and ring finger 2
chr11_-_120348475 1.659 ENSMUST00000062147.7
ENSMUST00000128055.1
 Actg1

actin, gamma, cytoplasmic 1

chr4_-_126753372 1.419 ENSMUST00000030637.7
ENSMUST00000106116.1
 Ncdn

neurochondrin

chr4_+_134468320 1.367 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
 Stmn1


stathmin 1


chr11_+_101155884 1.262 ENSMUST00000043654.9
 Tubg2
tubulin, gamma 2
chr4_+_85205120 1.212 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr2_-_85196697 1.204 ENSMUST00000099930.2
ENSMUST00000111601.1
 Lrrc55

leucine rich repeat containing 55

chr2_-_168742100 1.177 ENSMUST00000109177.1
 Atp9a
ATPase, class II, type 9A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 GO:0045214 sarcomere organization(GO:0045214)
0.5 4.3 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.1 3.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 3.1 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.6 2.3 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.7 2.2 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.1 2.2 GO:0048148 behavioral response to cocaine(GO:0048148)
0.0 2.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 1.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.6 GO:0007596 blood coagulation(GO:0007596)
0.1 1.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1 1.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 1.4 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 1.3 GO:0007020 microtubule nucleation(GO:0007020)
0.0 1.2 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 1.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 1.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 1.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 1.0 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956) diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.1 1.0 GO:0032482 Rab protein signal transduction(GO:0032482)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 GO:0031941 filamentous actin(GO:0031941)
0.0 3.8 GO:0055037 recycling endosome(GO:0055037)
0.0 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 2.3 GO:0005638 lamin filament(GO:0005638)
0.4 2.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 2.1 GO:0070382 exocytic vesicle(GO:0070382)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.1 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.2 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.4 1.1 GO:0044194 cytolytic granule(GO:0044194)
0.3 1.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 1.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 1.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.0 GO:0030133 transport vesicle(GO:0030133)
0.1 0.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.9 GO:0000502 proteasome complex(GO:0000502)
0.1 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.8 GO:0030118 clathrin coat(GO:0030118)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 3.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 2.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.4 2.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 1.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 1.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 1.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 1.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 1.0 GO:0030552 cAMP binding(GO:0030552)
0.1 0.9 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 0.8 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 0.8 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)