Motif ID: Hic2

Z-value: 2.550


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.714.7e-05Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 15.485 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_104231573 14.948 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr1_-_56978534 13.778 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr11_+_104231390 13.534 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr11_+_104231515 13.002 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_104231465 12.958 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr5_+_117781017 12.778 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr1_-_56969827 12.752 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_99224976 12.038 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr10_+_127725392 11.888 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr1_-_56969864 11.318 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr15_-_66831625 10.257 ENSMUST00000164163.1
 Sla
src-like adaptor
chr6_+_103510874 9.958 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr7_+_130936172 9.738 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr5_+_98180866 9.731 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr1_+_74854954 9.534 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr12_-_79007276 9.425 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr12_+_61523889 7.715 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_-_116654245 7.631 ENSMUST00000021166.5
 Cygb
cytoglobin
chr1_-_134234492 7.583 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 367 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 55.7 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
2.2 34.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
3.9 15.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.0 14.3 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
4.7 14.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
3.2 12.8 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
2.0 11.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.9 11.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.7 11.3 GO:0045792 negative regulation of cell size(GO:0045792)
0.3 11.1 GO:0035640 exploration behavior(GO:0035640)
0.6 10.7 GO:0001553 luteinization(GO:0001553)
2.1 10.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.7 10.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.6 9.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
2.4 9.5 GO:0021586 pons maturation(GO:0021586)
2.2 8.7 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.9 8.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 8.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 7.7 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.8 7.6 GO:2000489 hepatic stellate cell activation(GO:0035733) regulation of hepatic stellate cell activation(GO:2000489)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.4 54.4 GO:0045298 tubulin complex(GO:0045298)
0.4 46.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 27.2 GO:0031012 extracellular matrix(GO:0031012)
1.5 24.4 GO:0005614 interstitial matrix(GO:0005614)
0.4 23.5 GO:0042734 presynaptic membrane(GO:0042734)
0.4 18.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.9 17.0 GO:0032279 asymmetric synapse(GO:0032279)
0.5 14.1 GO:0030673 axolemma(GO:0030673)
1.2 12.8 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.6 12.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.4 11.7 GO:0032589 neuron projection membrane(GO:0032589)
0.2 10.7 GO:0043198 dendritic shaft(GO:0043198)
1.0 10.6 GO:0031931 TORC1 complex(GO:0031931)
0.4 10.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
3.2 9.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 8.9 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 8.8 GO:0009925 basal plasma membrane(GO:0009925)
0.8 8.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 8.3 GO:0044309 neuron spine(GO:0044309)
2.7 8.0 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 55.4 GO:0034185 apolipoprotein binding(GO:0034185)
2.6 15.5 GO:0045545 syndecan binding(GO:0045545)
2.0 14.1 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 13.4 GO:0005178 integrin binding(GO:0005178)
4.3 12.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.4 12.4 GO:0022839 ion gated channel activity(GO:0022839)
0.1 12.3 GO:0002020 protease binding(GO:0002020)
1.9 11.6 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.7 11.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.5 11.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.8 11.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.5 10.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 10.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.1 10.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 10.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.2 9.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.2 9.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 8.2 GO:0030552 cAMP binding(GO:0030552)
2.0 8.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 8.1 GO:0005520 insulin-like growth factor binding(GO:0005520)