Motif ID: Hif1a

Z-value: 0.939


Transcription factors associated with Hif1a:

Gene SymbolEntrez IDGene Name
Hif1a ENSMUSG00000021109.7 Hif1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73907904_73907970-0.262.0e-01Click!


Activity profile for motif Hif1a.

activity profile for motif Hif1a


Sorted Z-values histogram for motif Hif1a

Sorted Z-values for motif Hif1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hif1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_46845832 3.960 ENSMUST00000048209.9
ENSMUST00000092621.4
 Ldha

lactate dehydrogenase A

chr7_-_30973367 2.666 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973399 2.663 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr19_+_25610533 2.540 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr1_-_17097839 2.429 ENSMUST00000038382.4
 Jph1
junctophilin 1
chr18_+_74442500 2.054 ENSMUST00000074157.6
 Myo5b
myosin VB
chr2_+_27886416 1.937 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr16_+_70313949 1.918 ENSMUST00000163832.1
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr2_+_71873224 1.894 ENSMUST00000006669.5
 Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
chr3_-_95882193 1.888 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr16_+_70314087 1.788 ENSMUST00000023393.8
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chrX_-_93832106 1.775 ENSMUST00000045748.6
 Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr10_-_78009737 1.759 ENSMUST00000020522.8
 Pfkl
phosphofructokinase, liver, B-type
chr16_+_70314119 1.708 ENSMUST00000170464.2
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr4_-_55532453 1.683 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr16_+_70314057 1.643 ENSMUST00000171132.1
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr14_-_20181773 1.629 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr6_-_125165707 1.566 ENSMUST00000118875.1
 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr2_+_168081004 1.520 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr17_+_28769307 1.516 ENSMUST00000004986.6
 Mapk13
mitogen-activated protein kinase 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
1.8 5.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.8 4.0 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.9 3.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.7 3.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 3.0 GO:0071229 cellular response to acid chemical(GO:0071229)
0.0 2.6 GO:0006413 translational initiation(GO:0006413)
0.2 2.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.5 2.1 GO:0032439 endosome localization(GO:0032439)
0.2 2.1 GO:0019471 4-hydroxyproline metabolic process(GO:0019471)
0.0 2.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.6 1.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 1.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.6 1.8 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.2 1.8 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 1.8 GO:0030388 fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 1.7 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.2 1.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.6 GO:0009299 mRNA transcription(GO:0009299)
0.1 1.5 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 5.3 GO:0061689 tricellular tight junction(GO:0061689)
0.3 4.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.0 GO:0097452 GAIT complex(GO:0097452)
0.0 2.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.5 2.4 GO:0030314 junctional membrane complex(GO:0030314)
0.3 2.1 GO:0045179 apical cortex(GO:0045179)
0.6 1.9 GO:0005588 collagen type V trimer(GO:0005588)
0.6 1.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3 1.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.9 GO:0043196 varicosity(GO:0043196)
0.4 1.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 1.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 1.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 1.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.5 1.5 GO:0034455 t-UTP complex(GO:0034455)
0.0 1.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.5 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 1.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 1.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.1 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.3 5.3 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
1.0 4.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.9 3.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.0 3.0 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.3 2.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 2.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.3 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.0 2.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 1.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.6 1.8 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.4 1.8 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 1.8 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 1.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 1.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 1.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 1.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)