Motif ID: Hlf

Z-value: 0.631


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_903909260.535.8e-03Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_65971049 2.129 ENSMUST00000128539.1
 Clu
clusterin
chr14_+_65970804 1.993 ENSMUST00000138191.1
 Clu
clusterin
chr15_-_88978958 1.953 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr14_+_65971164 1.849 ENSMUST00000144619.1
 Clu
clusterin
chr4_-_151044564 1.432 ENSMUST00000103204.4
 Per3
period circadian clock 3
chr17_-_31637135 1.257 ENSMUST00000118504.1
ENSMUST00000078509.5
ENSMUST00000067801.6
 Cbs


cystathionine beta-synthase


chr3_+_127553462 1.212 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr19_-_50678642 1.170 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr11_-_101785252 1.043 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr18_-_80713062 1.041 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr9_-_107668967 0.976 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr5_-_3473178 0.973 ENSMUST00000168422.1
 Gm17590
predicted gene, 17590
chr5_+_3343893 0.972 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr3_-_80913528 0.946 ENSMUST00000107743.1
ENSMUST00000029654.8
 Glrb

glycine receptor, beta subunit

chr2_+_30834972 0.929 ENSMUST00000113592.2
 Prrx2
paired related homeobox 2
chr7_+_110773658 0.903 ENSMUST00000143786.1
 Ampd3
adenosine monophosphate deaminase 3
chr6_+_90465287 0.874 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr15_+_25758755 0.868 ENSMUST00000131834.1
ENSMUST00000124966.1
 Myo10

myosin X

chr2_-_129371131 0.844 ENSMUST00000028881.7
 Il1b
interleukin 1 beta
chr7_-_114636299 0.804 ENSMUST00000032906.4
ENSMUST00000032907.7
 Calca

calcitonin/calcitonin-related polypeptide, alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.0 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.4 2.2 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 1.6 GO:0032264 IMP salvage(GO:0032264)
0.1 1.4 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.4 1.3 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.3 1.0 GO:0060854 patterning of lymph vessels(GO:0060854)
0.3 1.0 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.2 1.0 GO:0006867 asparagine transport(GO:0006867) glutamine transport(GO:0006868)
0.2 1.0 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.2 1.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.1 0.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 0.9 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.9 GO:0042474 middle ear morphogenesis(GO:0042474)
0.3 0.8 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.3 0.8 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.0 0.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.7 GO:0006553 lysine metabolic process(GO:0006553)
0.2 0.7 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.2 0.7 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.1 0.7 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 2.0 GO:0005901 caveola(GO:0005901)
0.1 1.0 GO:0098536 deuterosome(GO:0098536)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.1 0.5 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0005745 m-AAA complex(GO:0005745)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.0 GO:0051787 misfolded protein binding(GO:0051787)
0.0 2.1 GO:0008565 protein transporter activity(GO:0008565)
0.2 1.6 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 1.3 GO:0098809 nitrite reductase activity(GO:0098809)
0.2 1.0 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.0 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
0.0 1.0 GO:0030332 cyclin binding(GO:0030332)
0.3 0.9 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.8 GO:0005179 hormone activity(GO:0005179)
0.2 0.7 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 0.7 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.2 0.6 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)