Motif ID: Hmbox1

Z-value: 1.302


Transcription factors associated with Hmbox1:

Gene SymbolEntrez IDGene Name
Hmbox1 ENSMUSG00000021972.8 Hmbox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmbox1mm10_v2_chr14_-_64949838_649498860.562.8e-03Click!


Activity profile for motif Hmbox1.

activity profile for motif Hmbox1


Sorted Z-values histogram for motif Hmbox1

Sorted Z-values for motif Hmbox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmbox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 13.450 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr6_+_5390387 13.338 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chrX_+_100625737 6.125 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr13_-_3893556 4.586 ENSMUST00000099946.4
 Net1
neuroepithelial cell transforming gene 1
chr3_-_100969644 4.413 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chrX_+_159303266 3.789 ENSMUST00000112491.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr10_+_22158566 3.639 ENSMUST00000181645.1
ENSMUST00000105522.2
 Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr7_-_25788635 3.193 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr10_+_39133981 3.189 ENSMUST00000019991.7
 Tube1
epsilon-tubulin 1
chr1_-_163289214 3.096 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr15_+_25773985 3.075 ENSMUST00000125667.1
 Myo10
myosin X
chr2_-_172043466 2.937 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chrX_+_169685191 2.847 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr13_-_74807913 2.787 ENSMUST00000065629.4
 Cast
calpastatin
chrX_-_23266751 2.754 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr3_-_95217690 2.639 ENSMUST00000107209.1
 Gabpb2
GA repeat binding protein, beta 2
chr1_-_75278345 2.451 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chrX_-_111537947 2.269 ENSMUST00000132319.1
ENSMUST00000123951.1
 Rps6ka6

ribosomal protein S6 kinase polypeptide 6

chr3_-_95217877 2.240 ENSMUST00000136139.1
 Gabpb2
GA repeat binding protein, beta 2
chr11_+_83942062 2.230 ENSMUST00000049257.7
 Ddx52
DEAD (Asp-Glu-Ala-Asp) box polypeptide 52

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 13.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.3 13.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.9 6.1 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 4.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.3 4.6 GO:0051451 myoblast migration(GO:0051451)
0.2 4.4 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.3 4.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 3.8 GO:0006821 chloride transport(GO:0006821)
0.1 3.6 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 3.6 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.4 3.5 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.8 3.2 GO:2000668 dendritic cell apoptotic process(GO:0097048) regulation of dendritic cell apoptotic process(GO:2000668)
0.3 3.1 GO:0048664 neuron fate determination(GO:0048664)
0.0 3.1 GO:0022409 positive regulation of cell-cell adhesion(GO:0022409)
0.4 2.8 GO:0007343 egg activation(GO:0007343)
0.1 2.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 2.3 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 2.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.1 GO:0000910 cytokinesis(GO:0000910)
0.3 1.9 GO:0006172 ADP biosynthetic process(GO:0006172)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 13.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 7.0 GO:0005871 kinesin complex(GO:0005871)
0.0 5.3 GO:0005874 microtubule(GO:0005874)
0.0 4.4 GO:0005681 spliceosomal complex(GO:0005681)
0.1 3.8 GO:0034707 chloride channel complex(GO:0034707)
1.2 3.6 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 3.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 3.2 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.1 2.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.5 2.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 2.3 GO:0016459 myosin complex(GO:0016459)
0.2 2.2 GO:0042788 polysomal ribosome(GO:0042788)
0.4 1.9 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 1.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.8 GO:0030315 T-tubule(GO:0030315)
0.0 1.8 GO:0005884 actin filament(GO:0005884)
0.0 1.8 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 1.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 1.5 GO:0070187 telosome(GO:0070187)
0.1 1.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 11.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5 7.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 6.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 5.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 4.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.2 4.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 4.5 GO:0005254 chloride channel activity(GO:0005254)
0.0 4.0 GO:0000287 magnesium ion binding(GO:0000287)
0.5 3.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.3 3.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 3.1 GO:0071837 HMG box domain binding(GO:0071837)
0.1 3.1 GO:0030507 spectrin binding(GO:0030507)
0.1 2.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 2.2 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.2 1.9 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.8 GO:0005522 profilin binding(GO:0005522)
0.6 1.7 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.4 1.7 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 1.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)