Motif ID: Hmx1

Z-value: 0.923


Transcription factors associated with Hmx1:

Gene SymbolEntrez IDGene Name
Hmx1 ENSMUSG00000067438.3 Hmx1



Activity profile for motif Hmx1.

activity profile for motif Hmx1


Sorted Z-values histogram for motif Hmx1

Sorted Z-values for motif Hmx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_147186389 5.664 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr7_-_144939823 5.301 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr12_+_109459843 4.914 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr2_+_164562579 4.327 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr7_-_48881032 3.790 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr1_+_52008210 3.615 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr6_+_30738044 3.488 ENSMUST00000128398.1
ENSMUST00000163949.2
ENSMUST00000124665.1
 Mest


mesoderm specific transcript


chr2_+_168081004 3.293 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr10_-_77113676 3.005 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr2_-_92370999 2.774 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr7_-_116308241 2.767 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr17_-_71310952 2.582 ENSMUST00000024849.9
 Emilin2
elastin microfibril interfacer 2
chr6_-_127151044 2.523 ENSMUST00000000188.8
 Ccnd2
cyclin D2
chr17_+_86963279 2.468 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr6_-_95718800 2.460 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr2_+_92915080 2.407 ENSMUST00000028648.2
 Syt13
synaptotagmin XIII
chr18_+_74442551 2.370 ENSMUST00000121875.1
 Myo5b
myosin VB
chr14_+_103070216 2.321 ENSMUST00000022721.6
 Cln5
ceroid-lipofuscinosis, neuronal 5
chr17_+_34592248 2.240 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr2_-_92371039 2.114 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.9 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 5.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.9 5.7 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.8 5.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 4.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.0 4.1 GO:0032439 endosome localization(GO:0032439)
0.2 3.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.3 3.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 3.7 GO:0010883 regulation of lipid storage(GO:0010883)
0.4 3.6 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 3.5 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.8 3.3 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.2 3.1 GO:0033327 Leydig cell differentiation(GO:0033327)
1.0 2.9 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.5 2.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 2.5 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 2.5 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 2.5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 2.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 2.1 GO:0008360 regulation of cell shape(GO:0008360)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 7.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 6.1 GO:0005581 collagen trimer(GO:0005581)
0.7 4.1 GO:0045179 apical cortex(GO:0045179)
0.2 3.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.2 2.9 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.0 2.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.4 2.5 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3 2.3 GO:0005775 vacuolar lumen(GO:0005775)
0.0 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.1 GO:0016528 sarcoplasm(GO:0016528)
0.6 1.8 GO:0044299 C-fiber(GO:0044299)
0.1 1.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.7 GO:0005643 nuclear pore(GO:0005643)
0.3 1.6 GO:0030314 junctional membrane complex(GO:0030314)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 7.1 GO:0005198 structural molecule activity(GO:0005198)
1.4 6.9 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.1 6.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 5.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 5.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 5.2 GO:0008134 transcription factor binding(GO:0008134)
0.1 4.4 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 4.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 3.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 3.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 3.2 GO:0005537 mannose binding(GO:0005537)
0.0 3.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.9 GO:0043236 laminin binding(GO:0043236)
0.1 2.6 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.2 2.5 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.2 2.5 GO:0005522 profilin binding(GO:0005522)
0.0 2.4 GO:0030276 clathrin binding(GO:0030276)
0.0 2.4 GO:0003729 mRNA binding(GO:0003729)
0.3 2.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)