Motif ID: Hmx2

Z-value: 0.478


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_1315487730.691.0e-04Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 2.414 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr5_-_28467093 1.830 ENSMUST00000002708.3
 Shh
sonic hedgehog
chr13_-_71963713 1.679 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr19_-_58454435 1.648 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr2_-_9878580 1.630 ENSMUST00000102976.3
 Gata3
GATA binding protein 3
chr12_+_117843873 1.480 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr14_+_73237891 1.116 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr18_-_65939048 1.050 ENSMUST00000025396.3
 Rax
retina and anterior neural fold homeobox
chr4_+_147492417 1.040 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr18_-_88894322 1.025 ENSMUST00000070116.5
ENSMUST00000125362.1
 Socs6

suppressor of cytokine signaling 6

chr18_+_50051702 0.979 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr5_-_28210022 0.961 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr5_+_23850590 0.907 ENSMUST00000181574.1
 2700038G22Rik
RIKEN cDNA 2700038G22 gene
chr3_+_109573907 0.901 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr4_-_62470868 0.836 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr5_-_53707532 0.815 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr2_+_35132194 0.784 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr11_-_100822525 0.762 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr12_-_98901478 0.752 ENSMUST00000065716.6
 Eml5
echinoderm microtubule associated protein like 5
chr13_-_59675754 0.737 ENSMUST00000022039.5
ENSMUST00000095739.2
 Golm1

golgi membrane protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 1.8 GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) kidney smooth muscle tissue development(GO:0072194) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.5 1.6 GO:0035799 ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0 1.1 GO:0021854 hypothalamus development(GO:0021854)
0.1 1.0 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 1.0 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 1.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.9 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.3 0.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.3 0.8 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.0 0.7 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.2 0.6 GO:0070269 pyroptosis(GO:0070269)
0.1 0.6 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.6 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 0.5 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 0.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.6 GO:0061702 inflammasome complex(GO:0061702)
0.1 0.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.3 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 1.8 GO:0005113 patched binding(GO:0005113)
0.3 1.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 1.6 GO:0005178 integrin binding(GO:0005178)
0.0 1.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.6 GO:0003690 double-stranded DNA binding(GO:0003690)
0.2 0.5 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.1 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0042974 retinoic acid receptor binding(GO:0042974)