Motif ID: Hoxa4

Z-value: 1.095


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_19103022 5.991 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr4_+_105790534 5.269 ENSMUST00000185012.1
 Gm12728
predicted gene 12728
chr2_+_71528657 4.831 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_+_90885860 4.668 ENSMUST00000111466.2
 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr14_-_79771305 4.314 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr1_-_52091066 4.300 ENSMUST00000105087.1
 Gm3940
predicted gene 3940
chr1_+_45981548 4.154 ENSMUST00000085632.2
 Rpl23a-ps1
ribosomal protein 23A, pseudogene 1
chr1_+_19208914 3.516 ENSMUST00000027059.4
 Tfap2b
transcription factor AP-2 beta
chr4_+_144892813 3.474 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_170731807 3.389 ENSMUST00000029075.4
 Dok5
docking protein 5
chr15_+_85116829 3.033 ENSMUST00000105085.1
 Gm10923
predicted gene 10923
chr7_-_19699008 2.874 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr11_+_57011945 2.852 ENSMUST00000094179.4
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr11_+_57011798 2.776 ENSMUST00000036315.9
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr13_+_94875600 2.774 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr18_+_37355271 2.769 ENSMUST00000051163.1
 Pcdhb8
protocadherin beta 8
chr4_+_144893077 2.672 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr18_-_31949571 2.513 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr5_+_17574726 2.439 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr9_+_51621425 2.390 ENSMUST00000089534.4
 Gm7293
predicted gene 7293

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.9 GO:0042572 retinol metabolic process(GO:0042572)
0.1 7.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 6.6 GO:0045838 positive regulation of membrane potential(GO:0045838)
1.6 4.8 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 4.6 GO:0030901 midbrain development(GO:0030901)
1.3 3.9 GO:0001928 regulation of exocyst assembly(GO:0001928)
1.2 3.5 GO:0097274 urea homeostasis(GO:0097274)
0.3 3.4 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 3.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.7 3.0 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
1.0 2.9 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.3 2.8 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.3 2.5 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.3 2.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 2.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 2.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 2.0 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 2.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 2.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.2 1.9 GO:0048625 myoblast fate commitment(GO:0048625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.9 5.6 GO:0044308 axonal spine(GO:0044308)
0.0 3.7 GO:0042641 actomyosin(GO:0042641)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
1.0 2.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 2.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.1 GO:0005902 microvillus(GO:0005902)
0.0 2.0 GO:0030139 endocytic vesicle(GO:0030139)
0.2 1.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.8 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.4 GO:0030315 T-tubule(GO:0030315)
0.1 1.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.2 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.0 6.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 5.0 GO:0005158 insulin receptor binding(GO:0005158)
0.2 3.9 GO:0030275 LRR domain binding(GO:0030275)
0.2 3.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
1.0 2.9 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 2.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 2.1 GO:0002039 p53 binding(GO:0002039)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 1.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.8 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 1.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 1.7 GO:0045296 cadherin binding(GO:0045296)
0.0 1.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 1.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 1.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 1.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 1.3 GO:0031402 sodium ion binding(GO:0031402)