Motif ID: Hoxa7_Hoxc8

Z-value: 0.560

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_86548268 2.627 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr3_+_55782500 1.770 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr8_+_45885479 1.393 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chr19_+_55895508 1.286 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr14_+_80000292 1.277 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr1_+_72284367 1.228 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr15_-_37458523 1.123 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr5_-_62766153 1.064 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 0.868 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chrX_-_143933089 0.840 ENSMUST00000087313.3
Dcx
doublecortin
chr15_-_8710409 0.791 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 0.781 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_125136692 0.725 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr18_+_23753708 0.714 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr3_+_55461758 0.672 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr2_+_109917639 0.667 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr6_-_118479237 0.647 ENSMUST00000161170.1
Zfp9
zinc finger protein 9
chr3_+_5218516 0.638 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr6_+_30541582 0.616 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr13_+_43785107 0.614 ENSMUST00000015540.2
Cd83
CD83 antigen
chr18_+_37518341 0.567 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr14_-_108914237 0.491 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr9_-_55919605 0.455 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr4_+_102589687 0.450 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr3_-_66296807 0.445 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr5_+_29195983 0.441 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
Rnf32




ring finger protein 32




chr18_-_10706688 0.411 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
Abhd3


abhydrolase domain containing 3


chr6_+_63255971 0.394 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr6_-_137169710 0.380 ENSMUST00000117919.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr3_+_5218546 0.374 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr3_+_5218589 0.361 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr9_-_103228420 0.359 ENSMUST00000126359.1
Trf
transferrin
chr14_+_64589802 0.356 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr13_+_42681513 0.354 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr3_-_59220150 0.350 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr7_+_126950687 0.326 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr10_+_116018213 0.322 ENSMUST00000063470.4
Ptprr
protein tyrosine phosphatase, receptor type, R
chr6_+_145934113 0.287 ENSMUST00000032383.7
Sspn
sarcospan
chr9_+_110052016 0.285 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr1_-_132367879 0.277 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr15_-_75905349 0.273 ENSMUST00000127550.1
Eef1d
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr5_-_62765618 0.270 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_-_14621805 0.268 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr14_-_48662740 0.262 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr4_-_115133977 0.258 ENSMUST00000051400.7
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr3_-_50443603 0.253 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr7_-_46667375 0.247 ENSMUST00000107669.2
Tph1
tryptophan hydroxylase 1
chr1_-_134955847 0.230 ENSMUST00000168381.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr1_-_127840290 0.225 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr10_+_23894688 0.221 ENSMUST00000041416.7
Vnn1
vanin 1
chr19_-_53944621 0.220 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chr9_+_113812547 0.214 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr19_-_50678642 0.211 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr2_+_69897220 0.201 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr1_-_134955908 0.192 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr5_+_66968559 0.189 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr17_-_45659312 0.188 ENSMUST00000120717.1
Capn11
calpain 11
chr16_-_45724600 0.180 ENSMUST00000096057.4
Tagln3
transgelin 3
chr4_+_100478806 0.180 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr4_-_14621494 0.178 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr11_+_29373618 0.173 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a

coiled coil domain containing 88A

chr15_-_67113909 0.169 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr2_+_69897255 0.169 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr17_-_36032682 0.166 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr19_-_32196393 0.165 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr19_+_5474681 0.164 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr6_+_134640940 0.142 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr10_-_20725023 0.142 ENSMUST00000020165.7
Pde7b
phosphodiesterase 7B
chr18_+_32067729 0.142 ENSMUST00000025243.3
Iws1
IWS1 homolog (S. cerevisiae)
chr10_+_115569986 0.135 ENSMUST00000173620.1
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr14_-_36919314 0.134 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr1_+_82316452 0.123 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr6_+_37870786 0.121 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr5_+_66968416 0.114 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr18_+_86711059 0.106 ENSMUST00000068423.3
Cbln2
cerebellin 2 precursor protein
chr2_-_164171113 0.105 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr7_+_38183217 0.082 ENSMUST00000165308.1
1600014C10Rik
RIKEN cDNA 1600014C10 gene
chrM_+_9870 0.080 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr11_+_102285161 0.076 ENSMUST00000156326.1
Tmub2
transmembrane and ubiquitin-like domain containing 2
chr1_-_24612700 0.074 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr18_-_75697639 0.073 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr2_-_177267036 0.066 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr18_-_3281036 0.064 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator


chr7_+_35802593 0.063 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr7_+_103550368 0.058 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr7_-_83550258 0.045 ENSMUST00000177929.1
Gm10610
predicted gene 10610
chr2_-_79456750 0.042 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr1_+_24177610 0.041 ENSMUST00000054588.8
Col9a1
collagen, type IX, alpha 1
chr8_+_94152607 0.025 ENSMUST00000034211.8
Mt3
metallothionein 3
chr2_+_23069210 0.024 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr19_+_41933464 0.016 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chrM_+_14138 0.012 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 0.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 1.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 2.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 0.6 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 1.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.4 GO:0019532 oxalate transport(GO:0019532)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 0.2 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.4 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.2 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 0.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.4 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.0 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.6 GO:0043205 fibril(GO:0043205)
0.1 1.3 GO:0042581 specific granule(GO:0042581)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.8 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 0.4 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 1.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.3 GO:0070330 aromatase activity(GO:0070330)
0.1 0.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.3 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.4 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)