Motif ID: Hoxb2_Dlx2

Z-value: 0.728

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.491.2e-02Click!


Activity profile for motif Hoxb2_Dlx2.

activity profile for motif Hoxb2_Dlx2


Sorted Z-values histogram for motif Hoxb2_Dlx2

Sorted Z-values for motif Hoxb2_Dlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 6.286 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_48665098 5.512 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr6_-_23248264 3.220 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_-_45470201 2.151 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr3_+_122419772 2.096 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr5_+_15516489 2.003 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr3_+_122044428 1.906 ENSMUST00000013995.8
 Abca4
ATP-binding cassette, sub-family A (ABC1), member 4
chr2_+_109917639 1.819 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr14_-_48662740 1.768 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr1_-_190170671 1.768 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr3_+_134236483 1.754 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr3_-_154328634 1.725 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr13_-_114458720 1.708 ENSMUST00000022287.5
 Fst
follistatin
chr13_-_102906046 1.652 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr7_+_144838590 1.652 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr6_+_4755327 1.607 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr6_-_124779686 1.579 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr2_-_72986716 1.554 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_+_55782500 1.533 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr3_+_159839729 1.486 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 6.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 3.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.7 2.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.9 2.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.4 2.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 2.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 2.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 2.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 2.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.3 1.9 GO:0030916 otic vesicle formation(GO:0030916)
0.6 1.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 1.8 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.6 1.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.4 1.7 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 1.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 1.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 1.5 GO:0031017 exocrine pancreas development(GO:0031017)
0.4 1.3 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 1.3 GO:0035095 behavioral response to nicotine(GO:0035095)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0030426 growth cone(GO:0030426)
0.5 3.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.1 0.7 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.6 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 8.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 2.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 2.9 GO:0030165 PDZ domain binding(GO:0030165)
0.3 2.8 GO:0050693 LBD domain binding(GO:0050693)
0.0 2.2 GO:0000287 magnesium ion binding(GO:0000287)
0.1 1.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 1.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.7 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.7 GO:0048185 activin binding(GO:0048185)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.1 1.3 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 1.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 1.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 1.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.0 GO:0005504 fatty acid binding(GO:0005504)