Motif ID: Hoxb5

Z-value: 1.227


Transcription factors associated with Hoxb5:

Gene SymbolEntrez IDGene Name
Hoxb5 ENSMUSG00000038700.3 Hoxb5



Activity profile for motif Hoxb5.

activity profile for motif Hoxb5


Sorted Z-values histogram for motif Hoxb5

Sorted Z-values for motif Hoxb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_125532377 11.276 ENSMUST00000031446.6
 Tmem132b
transmembrane protein 132B
chr6_-_18514802 6.503 ENSMUST00000090601.5
 Cttnbp2
cortactin binding protein 2
chr1_-_56971762 5.349 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr17_-_57087729 5.124 ENSMUST00000071135.5
 Tubb4a
tubulin, beta 4A class IVA
chr17_+_35076902 4.804 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr12_-_78980758 4.278 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr11_+_74619594 3.953 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr17_+_35077080 3.861 ENSMUST00000172959.1
 Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr12_-_78983476 3.821 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr2_+_158667119 3.763 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr19_-_45816007 3.469 ENSMUST00000079431.3
ENSMUST00000026247.6
ENSMUST00000162528.2
 Kcnip2


Kv channel-interacting protein 2


chr3_-_85722474 3.070 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chrX_-_165327376 3.054 ENSMUST00000058787.8
 Glra2
glycine receptor, alpha 2 subunit
chr7_+_3390629 2.570 ENSMUST00000182222.1
 Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr10_-_62143906 2.422 ENSMUST00000141724.1
ENSMUST00000150057.1
 2010107G23Rik

RIKEN cDNA 2010107G23 gene

chr2_-_153225396 2.398 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr5_+_117133567 2.311 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr3_-_89160155 2.150 ENSMUST00000029686.3
 Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr11_+_97798995 1.982 ENSMUST00000143571.1
 Lasp1
LIM and SH3 protein 1
chr13_+_88821472 1.889 ENSMUST00000118731.1
ENSMUST00000081769.6
 Edil3

EGF-like repeats and discoidin I-like domains 3

chr11_-_96075655 1.862 ENSMUST00000090541.5
 Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr10_-_81014902 1.849 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
 Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr13_+_88821606 1.780 ENSMUST00000043111.6
 Edil3
EGF-like repeats and discoidin I-like domains 3
chr11_-_96075581 1.764 ENSMUST00000107686.1
ENSMUST00000107684.1
 Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr7_+_119895836 1.746 ENSMUST00000106518.1
ENSMUST00000054440.3
 Lyrm1

LYR motif containing 1

chr7_+_19004047 1.713 ENSMUST00000053713.3
 Irf2bp1
interferon regulatory factor 2 binding protein 1
chrX_+_7723278 1.612 ENSMUST00000144148.1
 Wdr45
WD repeat domain 45
chr4_-_52497244 1.601 ENSMUST00000114578.4
 Vma21-ps
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene
chr7_-_31150981 1.547 ENSMUST00000085636.6
ENSMUST00000001280.7
 Gramd1a

GRAM domain containing 1A

chr14_+_32159865 1.502 ENSMUST00000163336.1
ENSMUST00000169722.1
ENSMUST00000168385.1
 Ncoa4


nuclear receptor coactivator 4


chr16_+_17070220 1.470 ENSMUST00000141959.1
 Ypel1
yippee-like 1 (Drosophila)
chr16_+_17070127 1.464 ENSMUST00000115729.1
 Ypel1
yippee-like 1 (Drosophila)
chr7_-_100964371 1.371 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_-_103737995 1.338 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr10_-_127211528 1.335 ENSMUST00000013970.7
 Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr10_+_21882184 1.317 ENSMUST00000120509.1
 Sgk1
serum/glucocorticoid regulated kinase 1
chr6_+_141249161 1.315 ENSMUST00000043259.7
 Pde3a
phosphodiesterase 3A, cGMP inhibited
chr15_-_28025834 1.285 ENSMUST00000090247.5
 Trio
triple functional domain (PTPRF interacting)
chr9_-_35116804 1.265 ENSMUST00000034537.6
 St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr8_-_85840877 1.251 ENSMUST00000034140.7
 Itfg1
integrin alpha FG-GAP repeat containing 1
chr14_+_55560010 1.242 ENSMUST00000147981.1
ENSMUST00000133256.1
 Dcaf11

DDB1 and CUL4 associated factor 11

chr7_+_16875302 1.235 ENSMUST00000108493.1
 Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr5_-_114273702 1.227 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr1_-_193370260 1.162 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr8_+_95081187 1.150 ENSMUST00000034239.7
 Katnb1
katanin p80 (WD40-containing) subunit B 1
chr5_-_103211251 1.133 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
 Mapk10



mitogen-activated protein kinase 10



chr9_-_35558522 1.122 ENSMUST00000034612.5
 Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr1_-_193370225 1.084 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr17_+_31386244 1.074 ENSMUST00000134525.1
ENSMUST00000127929.1
 Pde9a

phosphodiesterase 9A

chr10_+_80300997 1.069 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr14_+_55559993 1.066 ENSMUST00000117236.1
 Dcaf11
DDB1 and CUL4 associated factor 11
chr7_-_133709051 0.992 ENSMUST00000124759.1
ENSMUST00000106144.1
 Uros

uroporphyrinogen III synthase

chr8_-_25597459 0.975 ENSMUST00000079160.6
 Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr17_+_31386218 0.959 ENSMUST00000047168.5
 Pde9a
phosphodiesterase 9A
chr4_+_11704439 0.939 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr7_-_133708958 0.931 ENSMUST00000106146.1
 Uros
uroporphyrinogen III synthase
chr2_-_167062607 0.880 ENSMUST00000128676.1
 Znfx1
zinc finger, NFX1-type containing 1
chr11_+_4873951 0.861 ENSMUST00000038570.2
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr7_-_133709069 0.838 ENSMUST00000106145.3
 Uros
uroporphyrinogen III synthase
chr7_+_119896292 0.812 ENSMUST00000106517.1
 Lyrm1
LYR motif containing 1
chr9_+_20581296 0.812 ENSMUST00000115557.2
 Zfp846
zinc finger protein 846
chrX_-_10117597 0.777 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
 Srpx


sushi-repeat-containing protein


chr5_+_143933059 0.758 ENSMUST00000166847.1
 Rsph10b
radial spoke head 10 homolog B (Chlamydomonas)
chr7_-_119895697 0.737 ENSMUST00000059851.6
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr6_+_86438360 0.695 ENSMUST00000050497.7
 C87436
expressed sequence C87436
chr16_+_17070281 0.682 ENSMUST00000090199.3
 Ypel1
yippee-like 1 (Drosophila)
chr7_-_45466894 0.679 ENSMUST00000033093.8
 Bax
BCL2-associated X protein
chr14_-_63543931 0.670 ENSMUST00000058679.5
 Mtmr9
myotubularin related protein 9
chr14_-_41004517 0.663 ENSMUST00000153830.1
 Fam213a
family with sequence similarity 213, member A
chr4_+_86053887 0.653 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
 Adamtsl1



ADAMTS-like 1



chr8_+_123332676 0.647 ENSMUST00000010298.6
 Spire2
spire homolog 2 (Drosophila)
chr1_+_74544345 0.627 ENSMUST00000027362.7
 Plcd4
phospholipase C, delta 4
chr10_-_88683021 0.625 ENSMUST00000004473.8
 Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr17_-_47691403 0.611 ENSMUST00000113299.1
ENSMUST00000152214.1
 Gm21981
Prickle4
predicted gene 21981
prickle homolog 4 (Drosophila)
chr10_-_63927434 0.599 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr7_-_127208423 0.536 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chr7_-_109083284 0.379 ENSMUST00000120876.1
ENSMUST00000055993.6
 Ric3

resistance to inhibitors of cholinesterase 3 homolog (C. elegans)

chr12_-_36042476 0.375 ENSMUST00000020896.8
 Tspan13
tetraspanin 13
chr6_-_113501818 0.369 ENSMUST00000101059.1
 Prrt3
proline-rich transmembrane protein 3
chr4_-_108848619 0.340 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr7_-_119896285 0.286 ENSMUST00000106519.1
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr2_+_26973416 0.255 ENSMUST00000014996.7
ENSMUST00000102891.3
 Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr18_-_16809233 0.231 ENSMUST00000025166.7
 Cdh2
cadherin 2
chrX_+_7822289 0.195 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr2_+_85136355 0.137 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr17_+_47593516 0.092 ENSMUST00000182874.1
 Ccnd3
cyclin D3
chrX_+_20687954 0.084 ENSMUST00000115364.1
 Cdk16
cyclin-dependent kinase 16
chr7_-_123500449 0.081 ENSMUST00000042470.7
ENSMUST00000128217.1
 Zkscan2

zinc finger with KRAB and SCAN domains 2

chr6_+_121636173 0.058 ENSMUST00000032203.7
 A2m
alpha-2-macroglobulin
chr2_-_116065798 0.040 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.7 3.5 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.7 2.8 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.5 1.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 3.1 GO:0071361 cellular response to zinc ion(GO:0071294) cellular response to ethanol(GO:0071361)
0.4 1.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.3 5.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 1.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 8.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.3 0.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 0.7 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.2 0.6 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.2 1.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 1.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.3 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 1.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 3.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 2.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 2.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 2.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 2.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 1.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.0 GO:0010225 response to UV-C(GO:0010225)
0.1 0.2 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 3.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.6 GO:0007340 acrosome reaction(GO:0007340)
0.0 2.1 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 1.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.4 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.9 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 1.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.1 GO:0033269 internode region of axon(GO:0033269)
0.4 2.1 GO:0044316 cone cell pedicle(GO:0044316)
0.3 3.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.1 GO:0033391 chromatoid body(GO:0033391)
0.1 1.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.3 GO:0016342 catenin complex(GO:0016342)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 2.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 2.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 5.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 3.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)
0.0 5.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.1 GO:0005776 autophagosome(GO:0005776)
0.0 3.2 GO:0043204 perikaryon(GO:0043204)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.1 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
1.0 3.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.8 6.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.7 3.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 2.8 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.4 1.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.4 2.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 3.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.2 1.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 1.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 2.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.2 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)
0.1 1.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 5.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.0 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.3 GO:0030552 cAMP binding(GO:0030552)
0.0 3.6 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.9 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 3.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0019966 C-X-C chemokine binding(GO:0019958) interleukin-1 binding(GO:0019966) tumor necrosis factor binding(GO:0043120)
0.0 2.9 GO:0016247 channel regulator activity(GO:0016247)
0.0 1.1 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.0 2.0 GO:0051015 actin filament binding(GO:0051015)
0.0 1.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)