Motif ID: Hoxb7

Z-value: 3.953


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 24.547 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_+_19103022 22.078 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr8_+_54954728 19.040 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr4_+_102589687 17.884 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr16_+_42907563 17.684 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr15_+_21111452 17.474 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_136171722 16.458 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr16_+_7069825 16.199 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_+_71528657 15.567 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr19_+_26605106 15.223 ENSMUST00000025862.7
ENSMUST00000176030.1
 Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr1_-_56969827 15.031 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr5_+_117841839 14.990 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr6_-_13839916 14.264 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr1_-_56969864 13.781 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr17_+_3397189 13.544 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr3_+_18054258 13.484 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr1_+_177445660 13.470 ENSMUST00000077225.6
 Zbtb18
zinc finger and BTB domain containing 18
chr16_+_43247278 13.362 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20

chr6_-_55681257 12.442 ENSMUST00000044767.8
 Neurod6
neurogenic differentiation 6
chr3_+_55461758 11.797 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 406 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 56.4 GO:0006376 mRNA splice site selection(GO:0006376)
1.3 46.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
5.0 45.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
3.2 41.0 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 39.1 GO:0031032 actomyosin structure organization(GO:0031032)
2.4 38.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.0 32.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
1.5 32.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.0 30.6 GO:0060074 synapse maturation(GO:0060074)
9.8 29.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
4.8 28.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
2.5 28.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
3.5 27.9 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
2.1 27.2 GO:0070842 aggresome assembly(GO:0070842)
2.2 27.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.9 27.0 GO:0045161 neuronal ion channel clustering(GO:0045161)
5.1 25.6 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
2.7 24.3 GO:0071420 cellular response to histamine(GO:0071420)
0.3 22.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7 21.5 GO:0097090 presynaptic membrane organization(GO:0097090)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 124.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 60.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 45.4 GO:0000118 histone deacetylase complex(GO:0000118)
2.4 45.2 GO:0071564 npBAF complex(GO:0071564)
0.4 42.8 GO:0031225 anchored component of membrane(GO:0031225)
0.2 35.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.6 31.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 30.0 GO:0005768 endosome(GO:0005768)
1.2 28.0 GO:0000930 gamma-tubulin complex(GO:0000930)
2.5 27.9 GO:0043083 synaptic cleft(GO:0043083)
0.8 27.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.6 25.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.7 25.6 GO:0042734 presynaptic membrane(GO:0042734)
1.4 25.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.2 24.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 24.3 GO:0016607 nuclear speck(GO:0016607)
0.5 23.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 22.3 GO:0045202 synapse(GO:0045202)
1.4 21.1 GO:0031045 dense core granule(GO:0031045)
1.1 18.7 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 44.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.9 42.3 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.3 41.0 GO:0005057 receptor signaling protein activity(GO:0005057)
1.8 31.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 30.7 GO:0005262 calcium channel activity(GO:0005262)
0.2 30.6 GO:0003714 transcription corepressor activity(GO:0003714)
1.3 30.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.9 27.8 GO:0070412 R-SMAD binding(GO:0070412)
4.5 26.8 GO:0070699 type II activin receptor binding(GO:0070699)
1.4 25.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.8 24.4 GO:0001786 phosphatidylserine binding(GO:0001786)
1.7 21.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 21.7 GO:0008017 microtubule binding(GO:0008017)
2.1 21.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.4 21.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 20.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
1.8 20.2 GO:0003680 AT DNA binding(GO:0003680)
0.4 19.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.8 19.5 GO:0038191 neuropilin binding(GO:0038191)
0.5 16.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)