Motif ID: Hoxb8_Pdx1

Z-value: 0.736

Transcription factors associated with Hoxb8_Pdx1:

Gene SymbolEntrez IDGene Name
Hoxb8 ENSMUSG00000056648.4 Hoxb8
Pdx1 ENSMUSG00000029644.6 Pdx1



Activity profile for motif Hoxb8_Pdx1.

activity profile for motif Hoxb8_Pdx1


Sorted Z-values histogram for motif Hoxb8_Pdx1

Sorted Z-values for motif Hoxb8_Pdx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb8_Pdx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_11227511 9.967 ENSMUST00000080237.3
 Rpl21-ps4
ribosomal protein L21, pseudogene 4
chr13_-_85127514 3.655 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr9_+_51621425 3.239 ENSMUST00000089534.4
 Gm7293
predicted gene 7293
chr1_-_78968079 3.055 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr16_-_23890805 2.988 ENSMUST00000004480.3
 Sst
somatostatin
chr8_-_89187560 2.703 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr7_+_35802593 2.685 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chrX_+_140367494 2.024 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr15_+_21111452 1.890 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr9_+_40269202 1.618 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr9_+_40269273 1.565 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chrX_-_143933204 1.542 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr1_-_126830632 1.538 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr19_+_4711153 1.467 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr8_+_118283719 1.450 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr7_+_39588931 1.435 ENSMUST00000178791.1
ENSMUST00000098511.3
 Gm2058

predicted gene 2058

chr10_-_99759658 1.357 ENSMUST00000056085.4
 Csl
citrate synthase like
chrX_-_143933089 1.300 ENSMUST00000087313.3
 Dcx
doublecortin
chr8_+_83666827 1.188 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr1_-_56972437 1.172 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.2 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.2 2.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 2.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 2.0 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 1.8 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 1.5 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.4 1.4 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.1 1.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.1 GO:0097484 dendrite extension(GO:0097484)
0.2 1.0 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.1 1.0 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 1.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.2 0.8 GO:0031622 positive regulation of fever generation(GO:0031622)
0.0 0.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 0.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 1.9 GO:0045298 tubulin complex(GO:0045298)
0.0 1.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 1.5 GO:0008091 spectrin(GO:0008091)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.7 GO:0072534 perineuronal net(GO:0072534)
0.2 0.6 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.5 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.0 0.5 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 3.0 GO:0005179 hormone activity(GO:0005179)
0.1 2.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 2.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.6 1.8 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 1.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.3 1.3 GO:0055100 adiponectin binding(GO:0055100)
0.3 1.2 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 1.0 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.9 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.7 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 0.6 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.6 GO:0034946 2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.5 GO:0004984 olfactory receptor activity(GO:0004984)