Motif ID: Hoxc10

Z-value: 0.753


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_159737510 6.598 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_+_117841839 4.512 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr16_-_23988852 3.730 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr6_-_13839916 3.046 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr2_-_25469742 2.773 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr13_-_84064772 2.765 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr15_+_21111452 2.730 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr18_-_42899470 2.504 ENSMUST00000120632.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_-_42899294 2.452 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr4_+_144893127 1.955 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_-_36104060 1.890 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr2_-_25470031 1.884 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr15_+_81936753 1.751 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_81936911 1.739 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_92597104 1.648 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr2_+_178141920 1.593 ENSMUST00000103066.3
 Phactr3
phosphatase and actin regulator 3
chr17_-_90088343 1.561 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr17_-_91092715 1.471 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr15_-_58214882 1.463 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr17_+_31433054 1.455 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr11_-_79504078 1.385 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr2_+_32395896 1.341 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr1_-_69108039 1.229 ENSMUST00000121473.1
 Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr1_+_194619815 1.146 ENSMUST00000027952.5
 Plxna2
plexin A2
chr2_-_129371131 1.090 ENSMUST00000028881.7
 Il1b
interleukin 1 beta
chr5_+_71699918 1.088 ENSMUST00000031122.7
 Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr5_-_62766153 1.072 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_102254739 1.068 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr3_+_108591279 1.033 ENSMUST00000051145.8
ENSMUST00000139626.1
 Wdr47

WD repeat domain 47

chr8_+_83666827 1.014 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr9_+_113812547 0.873 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr15_+_6422240 0.865 ENSMUST00000163082.1
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chr2_-_144527341 0.768 ENSMUST00000163701.1
ENSMUST00000081982.5
 Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr9_-_116175318 0.724 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr1_+_179961110 0.692 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr3_-_123672321 0.672 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr1_+_180111339 0.608 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr3_-_146770218 0.596 ENSMUST00000106137.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr15_+_100761741 0.580 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr9_-_44799179 0.577 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr17_-_35074485 0.563 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr11_-_100146120 0.546 ENSMUST00000007317.7
 Krt19
keratin 19
chr7_-_73537621 0.534 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr6_-_136875794 0.522 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr9_+_53771499 0.521 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr8_-_41016295 0.507 ENSMUST00000131965.1
 Mtus1
mitochondrial tumor suppressor 1
chr1_+_66386968 0.492 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr2_+_73271925 0.424 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr17_-_46680870 0.422 ENSMUST00000165007.1
ENSMUST00000071841.5
 Klhdc3

kelch domain containing 3

chr18_-_70141568 0.414 ENSMUST00000121693.1
 Rab27b
RAB27b, member RAS oncogene family
chr7_-_29906087 0.411 ENSMUST00000053521.8
 Zfp27
zinc finger protein 27
chr13_-_91388079 0.398 ENSMUST00000181054.1
 A830009L08Rik
RIKEN cDNA A830009L08 gene
chr5_-_142906702 0.397 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr7_+_103550368 0.389 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr8_+_25720054 0.383 ENSMUST00000068916.8
ENSMUST00000139836.1
 Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr1_+_179960472 0.377 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr3_+_31902666 0.367 ENSMUST00000119970.1
ENSMUST00000178668.1
 Kcnmb2

potassium large conductance calcium-activated channel, subfamily M, beta member 2

chr8_-_94012558 0.352 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr11_+_29463735 0.340 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr15_-_79062866 0.325 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr5_-_111761697 0.295 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr2_-_32451396 0.288 ENSMUST00000028160.8
ENSMUST00000113310.2
 Slc25a25

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

chr7_-_30729505 0.273 ENSMUST00000006478.8
 Tmem147
transmembrane protein 147
chr1_+_191025350 0.258 ENSMUST00000181050.1
 A230020J21Rik
RIKEN cDNA A230020J21 gene
chr3_+_32436151 0.257 ENSMUST00000029201.7
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr5_-_62765618 0.252 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_84067063 0.250 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr17_+_33824591 0.250 ENSMUST00000048249.6
 Ndufa7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
chr11_+_115933282 0.249 ENSMUST00000140991.1
 Sap30bp
SAP30 binding protein
chr18_-_6490808 0.245 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr17_+_46681038 0.244 ENSMUST00000002845.6
 Mea1
male enhanced antigen 1
chr7_-_141434532 0.227 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
 Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr1_+_127729405 0.220 ENSMUST00000038006.6
 Acmsd
amino carboxymuconate semialdehyde decarboxylase
chr1_-_63114255 0.182 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr7_-_141435327 0.181 ENSMUST00000138865.1
 Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr9_+_50575273 0.141 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18

chr13_+_104287855 0.108 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr14_+_13453937 0.106 ENSMUST00000153954.1
 Synpr
synaptoporin
chr11_-_120549695 0.079 ENSMUST00000034913.4
 Fam195b
family with sequence similarity 195, member B
chr15_+_16778101 0.077 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr14_+_13454010 0.067 ENSMUST00000112656.2
 Synpr
synaptoporin
chr3_+_76074270 0.052 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr2_-_26122769 0.043 ENSMUST00000140993.1
ENSMUST00000028300.5
 Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr3_+_89266552 0.043 ENSMUST00000040824.1
 Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr11_-_97700327 0.027 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr9_+_37208291 0.026 ENSMUST00000034632.8
 Tmem218
transmembrane protein 218
chr6_-_124965485 0.023 ENSMUST00000112439.2
 Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr11_+_94211431 0.010 ENSMUST00000041589.5
 Tob1
transducer of ErbB-2.1
chr2_-_27463994 0.004 ENSMUST00000164296.1
 Brd3
bromodomain containing 3
chr19_-_7341792 0.001 ENSMUST00000164205.1
ENSMUST00000165286.1
ENSMUST00000168324.1
ENSMUST00000032557.8
 Mark2



MAP/microtubule affinity-regulating kinase 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.2 3.7 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.1 4.5 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.9 4.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.7 5.0 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.6 3.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.5 1.5 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.4 1.1 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092) positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.3 1.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 1.2 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.2 0.7 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.2 2.0 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.9 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 0.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 1.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 0.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 1.1 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.3 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 1.7 GO:0007097 nuclear migration(GO:0007097)
0.1 1.4 GO:0048679 regulation of axon regeneration(GO:0048679)
0.1 0.6 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.1 GO:0001866 NK T cell proliferation(GO:0001866) regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.4 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.6 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 1.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.3 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.5 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 0.3 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0072534 perineuronal net(GO:0072534)
0.4 4.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.3 0.9 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 4.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 0.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.1 1.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 5.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.4 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 3.7 GO:0005657 replication fork(GO:0005657)
0.0 1.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0070688 MLL5-L complex(GO:0070688)
0.0 2.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.0 GO:0005901 caveola(GO:0005901)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.5 GO:0043204 perikaryon(GO:0043204)
0.0 1.7 GO:0042641 actomyosin(GO:0042641)
0.0 0.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.2 4.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.4 1.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.4 6.6 GO:0046625 sphingolipid binding(GO:0046625)
0.4 5.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.3 3.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 2.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.0 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.3 3.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.2 GO:0038132 neuregulin binding(GO:0038132)
0.2 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.4 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 1.1 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 1.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 3.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)