Motif ID: Hoxc13_Hoxd13

Z-value: 0.789







Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56978534 6.055 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr10_-_8518801 4.683 ENSMUST00000061601.7
Ust
uronyl-2-sulfotransferase
chr5_+_17574268 3.707 ENSMUST00000030568.7
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr6_+_108213086 3.524 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr16_-_74411776 3.261 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr18_+_69346143 2.532 ENSMUST00000114980.1
Tcf4
transcription factor 4
chr17_+_75178911 2.276 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr14_-_118052235 1.973 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr13_+_16014457 1.932 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr17_+_75178797 1.902 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr9_+_32696005 1.056 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1


E26 avian leukemia oncogene 1, 5' domain


chr3_-_142169311 1.012 ENSMUST00000106230.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr17_-_6477102 0.991 ENSMUST00000167717.2
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr16_+_23226014 0.971 ENSMUST00000178797.1
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr8_+_112570043 0.859 ENSMUST00000034225.6
ENSMUST00000118171.1
Cntnap4

contactin associated protein-like 4

chr7_-_73537621 0.857 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr8_+_83666827 0.842 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr3_+_126597415 0.800 ENSMUST00000066452.7
ENSMUST00000171289.1
ENSMUST00000106399.1
Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr16_-_57231434 0.785 ENSMUST00000023431.6
Tbc1d23
TBC1 domain family, member 23
chr3_-_142169196 0.778 ENSMUST00000098568.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr4_+_54945038 0.753 ENSMUST00000133895.1
Zfp462
zinc finger protein 462
chr17_+_43568269 0.743 ENSMUST00000024706.5
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr3_+_126597299 0.712 ENSMUST00000106400.2
ENSMUST00000106401.1
Camk2d

calcium/calmodulin-dependent protein kinase II, delta

chr4_-_110290884 0.706 ENSMUST00000142722.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_48559971 0.695 ENSMUST00000169406.1
Gm1818
predicted gene 1818
chr5_-_62766153 0.674 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_43568641 0.667 ENSMUST00000169694.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr9_-_96719404 0.661 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr9_-_96719549 0.658 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr8_+_56551090 0.624 ENSMUST00000040218.5
ENSMUST00000110322.3
Fbxo8

F-box protein 8

chr17_+_6270475 0.605 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr17_-_90088343 0.585 ENSMUST00000173917.1
Nrxn1
neurexin I
chr1_-_156939387 0.579 ENSMUST00000171292.1
Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr17_+_8283762 0.557 ENSMUST00000155364.1
ENSMUST00000046754.8
ENSMUST00000124023.1
Mpc1


mitochondrial pyruvate carrier 1


chr12_-_34528844 0.540 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chr4_-_133602168 0.462 ENSMUST00000057311.3
Sfn
stratifin
chr17_+_43568475 0.442 ENSMUST00000167418.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_-_51826562 0.426 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chr8_-_70139197 0.351 ENSMUST00000075724.7
Rfxank
regulatory factor X-associated ankyrin-containing protein
chr2_-_127792467 0.332 ENSMUST00000135091.1
1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr3_+_59006978 0.325 ENSMUST00000040325.7
ENSMUST00000164225.1
ENSMUST00000040846.8
ENSMUST00000029393.8
Med12l



mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like



chr9_-_64022043 0.321 ENSMUST00000041029.5
Smad6
SMAD family member 6
chr1_-_74124420 0.314 ENSMUST00000169786.1
Tns1
tensin 1
chr3_+_76074270 0.312 ENSMUST00000038364.8
Fstl5
follistatin-like 5
chr18_+_37484955 0.310 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr2_-_66440753 0.299 ENSMUST00000112371.2
ENSMUST00000138910.1
Scn1a

sodium channel, voltage-gated, type I, alpha

chr9_-_77347816 0.284 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr18_+_37355271 0.240 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr3_+_79885930 0.235 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr18_-_46280820 0.234 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr9_-_77347787 0.228 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr11_-_95699143 0.225 ENSMUST00000062249.2
Gm9796
predicted gene 9796
chr13_-_23571151 0.223 ENSMUST00000102969.3
Hist1h2ae
histone cluster 1, H2ae
chr12_+_69963452 0.218 ENSMUST00000110560.1
Gm3086
predicted gene 3086
chr1_-_163289214 0.205 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr10_-_120979327 0.204 ENSMUST00000119944.1
ENSMUST00000119093.1
Lemd3

LEM domain containing 3

chr4_-_82850721 0.198 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr1_-_36273425 0.183 ENSMUST00000056946.6
Neurl3
neuralized homolog 3 homolog (Drosophila)
chr5_-_62765618 0.158 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_21879662 0.155 ENSMUST00000029909.2
Coq3
coenzyme Q3 homolog, methyltransferase (yeast)
chr14_-_103346765 0.137 ENSMUST00000159855.1
Mycbp2
MYC binding protein 2
chr5_+_86804214 0.128 ENSMUST00000119339.1
ENSMUST00000120498.1
Ythdc1

YTH domain containing 1

chr5_+_105876532 0.113 ENSMUST00000150440.1
ENSMUST00000031227.4
Zfp326

zinc finger protein 326

chr17_-_13761441 0.093 ENSMUST00000127032.1
Tcte2
t-complex-associated testis expressed 2
chr13_-_21402688 0.091 ENSMUST00000117721.1
ENSMUST00000070785.8
ENSMUST00000116433.1
ENSMUST00000116434.3
Zkscan3



zinc finger with KRAB and SCAN domains 3



chr14_+_77156733 0.085 ENSMUST00000022589.7
Enox1
ecto-NOX disulfide-thiol exchanger 1
chr1_+_59256906 0.084 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr11_-_23895208 0.084 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr7_-_119895446 0.078 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr8_+_34807287 0.074 ENSMUST00000033930.4
Dusp4
dual specificity phosphatase 4
chr2_+_112265809 0.070 ENSMUST00000110991.2
Slc12a6
solute carrier family 12, member 6
chr14_-_76110760 0.060 ENSMUST00000022585.3
Gpalpp1
GPALPP motifs containing 1
chr6_+_134929089 0.049 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
RP23-45G16.5


RP23-45G16.5


chrX_-_136868537 0.046 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr9_+_92542223 0.046 ENSMUST00000070522.7
ENSMUST00000160359.1
Plod2

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

chr3_+_95658771 0.040 ENSMUST00000178686.1
Mcl1
myeloid cell leukemia sequence 1
chr4_-_136602641 0.030 ENSMUST00000105847.1
ENSMUST00000116273.2
Kdm1a

lysine (K)-specific demethylase 1A

chr8_+_33653238 0.026 ENSMUST00000033992.8
Gsr
glutathione reductase
chr9_-_77347889 0.012 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr11_+_77216180 0.003 ENSMUST00000037912.5
ENSMUST00000156488.1
Ssh2

slingshot homolog 2 (Drosophila)


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.6 3.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.5 3.7 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.4 1.8 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.4 1.9 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.4 6.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 1.9 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.3 2.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 1.5 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.3 1.1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.3 2.5 GO:0042118 endothelial cell activation(GO:0042118)
0.2 1.0 GO:1990743 protein sialylation(GO:1990743)
0.2 0.6 GO:0009405 pathogenesis(GO:0009405)
0.1 3.8 GO:0044253 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.1 0.6 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 0.6 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 0.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.9 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 0.2 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1 0.5 GO:0031424 keratinization(GO:0031424)
0.1 0.5 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.4 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 3.1 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.2 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.0 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.0 0.8 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.8 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.1 GO:0071476 hypotonic response(GO:0006971) cellular hypotonic response(GO:0071476)
0.0 0.1 GO:2000773 negative regulation of cellular senescence(GO:2000773)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.2 3.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.6 1.9 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 3.3 GO:0030673 axolemma(GO:0030673)
0.1 1.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 2.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 6.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.8 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.0 4.2 GO:0050436 microfibril binding(GO:0050436)
0.6 2.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 3.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 3.7 GO:0038191 neuropilin binding(GO:0038191)
0.3 1.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 0.3 GO:0070697 activin receptor binding(GO:0070697)
0.2 0.8 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.2 1.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.2 1.8 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 1.5 GO:0031432 titin binding(GO:0031432)
0.1 4.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 2.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.5 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)