Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.739

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:

Gene SymbolEntrez IDGene Name
Arx ENSMUSG00000035277.9 Arx
Esx1 ENSMUSG00000023443.7 Esx1
Hoxc4 ENSMUSG00000075394.3 Hoxc4
Otp ENSMUSG00000021685.10 Otp
Phox2b ENSMUSG00000012520.8 Phox2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arxmm10_v2_chrX_+_93286499_932865220.193.5e-01Click!
Otpmm10_v2_chr13_+_94875600_94875611-0.106.2e-01Click!


Activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b.

activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b


Sorted Z-values histogram for motif Hoxc4_Arx_Otp_Esx1_Phox2b

Sorted Z-values for motif Hoxc4_Arx_Otp_Esx1_Phox2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_105789869 6.568 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr17_+_82539258 2.776 ENSMUST00000097278.3
 Gm6594
predicted pseudogene 6594
chr14_+_58893465 1.980 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr2_+_20737306 1.593 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr4_+_145585166 1.476 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr17_-_48432723 1.361 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_+_119063429 1.221 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr5_+_13398688 0.952 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_+_145510759 0.950 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr4_+_108719649 0.908 ENSMUST00000178992.1
 3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr2_-_73580288 0.885 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr10_+_37139558 0.819 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr4_-_14621805 0.792 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr12_-_84617326 0.775 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr14_-_5863663 0.737 ENSMUST00000178594.1
 Gm8237
predicted gene 8237
chr7_+_39588931 0.734 ENSMUST00000178791.1
ENSMUST00000098511.3
 Gm2058

predicted gene 2058

chr14_+_4198185 0.548 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chr2_+_119047129 0.529 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr13_+_23533869 0.527 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr4_-_14621494 0.508 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0019532 oxalate transport(GO:0019532)
0.1 1.4 GO:0080111 DNA demethylation(GO:0080111)
0.0 1.1 GO:0051693 actin filament capping(GO:0051693)
0.2 1.0 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 0.9 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.9 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 0.5 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.4 GO:0006953 acute-phase response(GO:0006953)
0.0 0.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.3 GO:0031272 regulation of pseudopodium assembly(GO:0031272)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.1 0.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.0 GO:0031417 NatC complex(GO:0031417)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.9 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.3 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.1 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)