Motif ID: Hoxd10

Z-value: 0.392


Transcription factors associated with Hoxd10:

Gene SymbolEntrez IDGene Name
Hoxd10 ENSMUSG00000050368.3 Hoxd10



Activity profile for motif Hoxd10.

activity profile for motif Hoxd10


Sorted Z-values histogram for motif Hoxd10

Sorted Z-values for motif Hoxd10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_27790947 2.726 ENSMUST00000115243.2
Opcml
opioid binding protein/cell adhesion molecule-like
chr8_-_84773381 2.451 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr3_-_80802789 1.468 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr18_-_78123324 1.150 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr4_+_102254993 1.007 ENSMUST00000106908.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr8_-_109251698 0.761 ENSMUST00000079189.3
4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr2_+_65620829 0.707 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chrX_+_66653003 0.686 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr7_+_96210107 0.648 ENSMUST00000138760.1
Tenm4
teneurin transmembrane protein 4
chrX_-_70365052 0.590 ENSMUST00000101509.2
Ids
iduronate 2-sulfatase
chr3_+_86084434 0.567 ENSMUST00000107664.2
Sh3d19
SH3 domain protein D19
chr9_+_104569671 0.562 ENSMUST00000057742.8
Cpne4
copine IV
chr3_+_55461758 0.527 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr4_+_43401232 0.364 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr10_+_69534039 0.353 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr15_+_9140527 0.311 ENSMUST00000090380.4
Lmbrd2
LMBR1 domain containing 2
chr1_+_180111339 0.294 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr17_+_78508063 0.290 ENSMUST00000024880.9
Vit
vitrin
chr6_+_33249085 0.280 ENSMUST00000052266.8
ENSMUST00000090381.4
ENSMUST00000115080.1
Exoc4


exocyst complex component 4


chr7_+_30095150 0.263 ENSMUST00000130526.1
ENSMUST00000108200.1
Zfp260

zinc finger protein 260

chr2_+_21367532 0.220 ENSMUST00000055946.7
Gpr158
G protein-coupled receptor 158
chr2_+_106693185 0.216 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr10_+_116177351 0.198 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr1_-_152625212 0.197 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr19_+_37436707 0.182 ENSMUST00000128184.1
Hhex
hematopoietically expressed homeobox
chr5_-_122697603 0.167 ENSMUST00000071235.4
Gm10064
predicted gene 10064
chr4_+_19605451 0.144 ENSMUST00000108250.2
Gm12353
predicted gene 12353
chr9_+_95857597 0.119 ENSMUST00000034980.7
Atr
ataxia telangiectasia and Rad3 related
chr14_-_93888732 0.096 ENSMUST00000068992.2
Pcdh9
protocadherin 9
chr13_+_49582745 0.093 ENSMUST00000065494.7
Omd
osteomodulin
chr11_-_110168073 0.086 ENSMUST00000044850.3
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr17_-_46327949 0.070 ENSMUST00000047970.7
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr7_+_81862674 0.053 ENSMUST00000119543.1
Tm6sf1
transmembrane 6 superfamily member 1
chr9_-_90255927 0.052 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr15_+_57912199 0.043 ENSMUST00000022992.6
Tbc1d31
TBC1 domain family, member 31
chr18_-_6490808 0.039 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr1_-_132390301 0.037 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr10_-_49783259 0.023 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr7_-_73541738 0.017 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2
chr18_-_75697639 0.010 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.2 2.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 1.1 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.2 0.6 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 1.0 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.2 GO:0061010 gall bladder development(GO:0061010)
0.0 0.1 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.3 GO:0007097 nuclear migration(GO:0007097)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.1 GO:0015265 urea channel activity(GO:0015265)
0.1 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 1.0 GO:0030552 cAMP binding(GO:0030552)
0.0 0.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)