Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.739

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_3397189 6.651 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr13_-_84064772 6.623 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr1_+_159737510 6.244 ENSMUST00000111669.3
 Tnr
tenascin R
chr4_+_105789869 5.236 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr4_+_144893127 5.179 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr15_+_81936911 4.517 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr4_+_105790534 4.038 ENSMUST00000185012.1
 Gm12728
predicted gene 12728
chr15_+_81936753 3.864 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr17_-_91092715 3.592 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr4_+_144892813 3.547 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_-_13839916 2.930 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr4_+_144893077 2.656 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_-_56969827 2.608 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr17_+_31433054 2.541 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr18_+_69593361 2.358 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr2_+_32395896 2.337 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr4_-_64046925 2.283 ENSMUST00000107377.3
 Tnc
tenascin C
chr5_-_62766153 2.261 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_56969864 2.236 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr7_-_142661858 2.218 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 6.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
2.1 6.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 4.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 4.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.4 3.0 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.3 2.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 2.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 2.5 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.2 2.4 GO:0042118 endothelial cell activation(GO:0042118)
0.6 2.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.3 2.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 2.2 GO:0006342 chromatin silencing(GO:0006342)
0.3 2.1 GO:0016584 nucleosome positioning(GO:0016584)
0.1 2.0 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.5 1.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 1.9 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.6 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.3 1.3 GO:0019236 response to pheromone(GO:0019236)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 6.2 GO:0072534 perineuronal net(GO:0072534)
0.1 5.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 5.0 GO:0000786 nucleosome(GO:0000786)
0.1 4.2 GO:0042734 presynaptic membrane(GO:0042734)
0.2 3.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.6 GO:0043204 perikaryon(GO:0043204)
0.1 2.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.4 GO:0005795 Golgi stack(GO:0005795)
0.1 1.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.1 GO:0044306 neuron projection terminus(GO:0044306)
0.1 1.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 0.8 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 6.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 6.2 GO:0046625 sphingolipid binding(GO:0046625)
0.4 4.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 3.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 2.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 2.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.6 2.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.6 2.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.4 2.3 GO:0045545 syndecan binding(GO:0045545)
0.1 2.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 2.1 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 2.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 1.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 1.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 1.5 GO:0016749 N-succinyltransferase activity(GO:0016749)
0.0 1.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.1 GO:0016208 AMP binding(GO:0016208)
0.3 1.0 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)