Motif ID: Hoxd12

Z-value: 0.620


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710409 1.650 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 1.593 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62766153 1.515 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_159737510 1.485 ENSMUST00000111669.3
 Tnr
tenascin R
chr16_+_42907563 1.385 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr4_+_144893127 1.334 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_122419772 1.274 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr4_+_144892813 1.271 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr13_-_84064772 1.042 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144893077 1.013 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_-_56969864 0.989 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_105789869 0.951 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr2_-_114013619 0.943 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr15_+_81936911 0.857 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr13_-_101692624 0.826 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr17_-_91092715 0.821 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr2_+_73271925 0.809 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr1_-_56969827 0.795 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_105790534 0.767 ENSMUST00000185012.1
 Gm12728
predicted gene 12728
chr5_-_62765618 0.759 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.6 GO:0042572 retinol metabolic process(GO:0042572)
0.8 3.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 1.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.5 1.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 1.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 1.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.8 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 0.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 0.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 0.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.7 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.6 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 0.4 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.4 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.1 0.3 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0043205 fibril(GO:0043205)
0.0 2.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 1.5 GO:0072534 perineuronal net(GO:0072534)
0.0 1.4 GO:0016607 nuclear speck(GO:0016607)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 0.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.3 GO:0070820 tertiary granule(GO:0070820)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.6 3.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 2.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.5 GO:0046625 sphingolipid binding(GO:0046625)
0.1 1.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 0.8 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.2 0.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.5 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.4 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.1 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)