Motif ID: Hoxd8

Z-value: 0.526


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_85127514 1.793 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr3_+_94372794 1.413 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr17_-_48432723 1.099 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr3_+_127633134 0.946 ENSMUST00000029587.7
Neurog2
neurogenin 2
chrX_+_56786527 0.909 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr3_-_19264959 0.889 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr9_+_54538984 0.709 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr8_-_106573461 0.658 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr1_-_172027269 0.627 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr1_-_158814469 0.585 ENSMUST00000161589.2
Pappa2
pappalysin 2
chr14_+_58893465 0.579 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr12_-_87444017 0.566 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr1_-_126830632 0.525 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr1_-_138848576 0.525 ENSMUST00000112030.2
Lhx9
LIM homeobox protein 9
chr12_-_84617326 0.483 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr1_+_178798438 0.477 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr19_+_23723279 0.438 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr4_-_132398199 0.408 ENSMUST00000136711.1
ENSMUST00000084249.4
Phactr4

phosphatase and actin regulator 4

chr1_-_126830786 0.396 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr8_-_84662841 0.367 ENSMUST00000060427.4
Ier2
immediate early response 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.0 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2 0.8 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 0.6 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.6 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.2 0.5 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.4 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.4 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 0.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.2 GO:0017144 drug metabolic process(GO:0017144)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.6 GO:0060187 cell pole(GO:0060187)
0.0 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.3 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 0.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.4 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.1 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.4 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)