Motif ID: Hsf1

Z-value: 0.686


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_764774610.193.6e-01Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 4.364 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr7_-_70366735 3.007 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr12_-_110696332 1.342 ENSMUST00000094361.4
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chrX_+_71663665 1.189 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr12_-_110696289 1.127 ENSMUST00000021698.6
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr12_-_110696248 1.062 ENSMUST00000124156.1
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr12_-_110695860 1.040 ENSMUST00000149189.1
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr2_+_120463566 0.925 ENSMUST00000028749.7
ENSMUST00000110721.1
 Capn3

calpain 3

chr19_-_7039987 0.924 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr7_-_99353104 0.869 ENSMUST00000169437.1
ENSMUST00000094154.4
 Serpinh1

serine (or cysteine) peptidase inhibitor, clade H, member 1

chr12_+_117843873 0.827 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr9_+_40801235 0.816 ENSMUST00000117870.1
ENSMUST00000117557.1
 Hspa8

heat shock protein 8

chr5_-_149636164 0.814 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr5_+_115908644 0.751 ENSMUST00000141101.1
 Cit
citron
chr6_-_128438673 0.725 ENSMUST00000032508.4
 Fkbp4
FK506 binding protein 4
chr1_-_55088024 0.640 ENSMUST00000027123.8
 Hspd1
heat shock protein 1 (chaperonin)
chr1_+_57774600 0.630 ENSMUST00000167971.1
ENSMUST00000170139.1
ENSMUST00000171699.1
ENSMUST00000164302.1
 Spats2l



spermatogenesis associated, serine-rich 2-like



chr17_+_47593444 0.599 ENSMUST00000182209.1
 Ccnd3
cyclin D3
chr10_-_86705485 0.582 ENSMUST00000020238.7
 Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr1_+_57774842 0.581 ENSMUST00000167085.1
 Spats2l
spermatogenesis associated, serine-rich 2-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.6 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
1.1 4.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 3.0 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.2 1.8 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.3 1.3 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.3 1.1 GO:0030576 Cajal body organization(GO:0030576)
0.3 1.0 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.3 0.9 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.9 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.1 0.9 GO:0031053 primary miRNA processing(GO:0031053)
0.3 0.8 GO:1903054 lysosomal membrane organization(GO:0097212) negative regulation of extracellular matrix organization(GO:1903054) positive regulation of protein folding(GO:1903334)
0.0 0.8 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.8 GO:0006825 copper ion transport(GO:0006825)
0.1 0.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.7 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.1 0.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.6 GO:0071318 cellular response to ATP(GO:0071318)
0.1 0.5 GO:0060032 notochord regression(GO:0060032)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.6 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 4.6 GO:0030426 growth cone(GO:0030426)
0.2 1.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.2 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.1 GO:0015030 Cajal body(GO:0015030)
0.2 1.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 1.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.9 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.2 0.8 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.8 GO:0031985 Golgi cisterna(GO:0031985)
0.1 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0097542 ciliary tip(GO:0097542)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.4 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7 4.4 GO:0002135 CTP binding(GO:0002135)
0.3 3.0 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 1.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 1.1 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.1 1.0 GO:0043559 insulin binding(GO:0043559)
0.2 0.9 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.9 GO:0031432 titin binding(GO:0031432)
0.0 0.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 0.8 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.8 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.7 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.6 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.6 GO:0046790 virion binding(GO:0046790)
0.2 0.5 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.5 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)