Motif ID: Hsf2

Z-value: 2.251


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_574864140.471.6e-02Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 9.308 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr17_-_70851189 8.826 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr14_-_48667508 8.710 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr17_-_70849644 8.046 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr17_-_25797032 7.661 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr7_-_4752972 6.427 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr11_+_120949053 6.380 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
 Slc16a3



solute carrier family 16 (monocarboxylic acid transporters), member 3



chr10_+_84838143 6.021 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr10_+_121033960 5.759 ENSMUST00000020439.4
ENSMUST00000175867.1
 Wif1

Wnt inhibitory factor 1

chr11_-_11970540 5.525 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr9_+_7764041 5.420 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123
chr7_+_16781341 5.337 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr12_-_91746020 5.208 ENSMUST00000166967.1
 Ston2
stonin 2
chr5_-_5514730 5.205 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr18_+_50053282 5.092 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr12_-_10900296 4.939 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr5_-_5514873 4.930 ENSMUST00000060947.7
 Cldn12
claudin 12
chr1_-_138847579 4.857 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_+_30061754 4.786 ENSMUST00000149578.1
ENSMUST00000102866.3
 Set

SET nuclear oncogene

chr13_-_3918157 4.698 ENSMUST00000091853.4
 Net1
neuroepithelial cell transforming gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 257 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 21.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.8 10.7 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.4 10.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 10.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.5 9.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
2.2 8.9 GO:0021698 cerebellar cortex structural organization(GO:0021698)
2.2 8.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.4 8.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 7.8 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 7.5 GO:0046596 regulation of viral entry into host cell(GO:0046596)
0.1 7.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.4 6.5 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.3 6.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.0 6.2 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
1.5 6.0 GO:2000974 negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of pro-B cell differentiation(GO:2000974) negative regulation of inner ear receptor cell differentiation(GO:2000981)
1.2 6.0 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.3 5.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.9 5.6 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.6 5.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 5.3 GO:0045793 positive regulation of cell size(GO:0045793)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.8 GO:0031965 nuclear membrane(GO:0031965)
2.1 10.7 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 10.7 GO:0005730 nucleolus(GO:0005730)
0.2 10.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 9.4 GO:0016459 myosin complex(GO:0016459)
0.1 8.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 7.9 GO:0045180 basal cortex(GO:0045180)
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.2 7.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 6.8 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.5 6.4 GO:0030061 mitochondrial crista(GO:0030061)
0.1 6.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.8 6.1 GO:0005818 aster(GO:0005818)
0.9 5.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 5.4 GO:0005802 trans-Golgi network(GO:0005802)
0.2 4.6 GO:0051233 spindle midzone(GO:0051233)
0.7 4.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 4.5 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 4.5 GO:0031985 Golgi cisterna(GO:0031985)
1.1 4.4 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0 21.0 GO:0070410 co-SMAD binding(GO:0070410)
0.6 11.4 GO:0008307 structural constituent of muscle(GO:0008307)
1.8 10.6 GO:0002135 CTP binding(GO:0002135)
0.2 7.4 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.3 6.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 6.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 6.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.2 6.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.2 6.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.4 5.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.7 5.6 GO:0043559 insulin binding(GO:0043559)
0.3 5.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 5.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 5.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.2 4.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 4.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 4.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 4.7 GO:0005109 frizzled binding(GO:0005109)