Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.465

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770014_537700570.591.4e-03Click!
Irf9mm10_v2_chr14_+_55604550_556045790.413.9e-02Click!
Irf7mm10_v2_chr7_-_141266415_1412664810.395.2e-02Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.252.2e-01Click!
Irf2mm10_v2_chr8_+_46739745_467397910.086.8e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3034599 22.597 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3013140 21.900 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3015654 21.812 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3023547 20.952 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3017408 20.065 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3004457 19.692 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3027439 19.687 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr14_-_19418930 18.971 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3005125 18.773 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3000922 18.718 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr2_-_98667264 18.476 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3037111 17.863 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 16.766 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3018753 16.432 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3025417 16.378 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chrX_-_134161928 10.089 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr14_+_14012491 8.652 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr2_+_98662227 7.796 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr7_-_102565425 7.743 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr16_-_35939082 7.152 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 313 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.9 GO:0071346 cellular response to interferon-gamma(GO:0071346)
1.3 9.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.1 9.0 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
1.1 8.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.2 8.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.7 8.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
1.5 7.7 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.2 7.1 GO:0010390 histone monoubiquitination(GO:0010390)
0.5 6.4 GO:0044458 motile cilium assembly(GO:0044458)
1.4 5.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.9 5.7 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.5 4.8 GO:0085020 protein K6-linked ubiquitination(GO:0085020)
0.4 4.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 4.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.8 4.2 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.2 4.2 GO:0006379 mRNA cleavage(GO:0006379)
0.3 4.1 GO:0097066 response to thyroid hormone(GO:0097066)
0.2 3.9 GO:0035855 megakaryocyte development(GO:0035855)
1.0 3.8 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1 3.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 15.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 11.0 GO:0016605 PML body(GO:0016605)
0.4 8.5 GO:0030914 STAGA complex(GO:0030914)
0.0 8.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 8.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 6.5 GO:0036126 sperm flagellum(GO:0036126)
1.5 6.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 4.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 4.2 GO:0031519 PcG protein complex(GO:0031519)
0.1 4.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 4.0 GO:1990462 omegasome(GO:1990462)
1.3 3.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 3.7 GO:0005614 interstitial matrix(GO:0005614)
0.4 3.5 GO:0030478 actin cap(GO:0030478)
0.4 3.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 3.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 3.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.5 3.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.4 3.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.5 3.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.5 12.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 10.1 GO:0004386 helicase activity(GO:0004386)
0.7 9.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 7.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 6.9 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.5 6.7 GO:0031386 protein tag(GO:0031386)
1.5 6.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.2 6.0 GO:0032027 myosin light chain binding(GO:0032027)
0.0 5.5 GO:0005525 GTP binding(GO:0005525)
0.0 5.2 GO:0003682 chromatin binding(GO:0003682)
0.4 5.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 4.9 GO:0001848 complement binding(GO:0001848)
0.3 4.8 GO:0017166 vinculin binding(GO:0017166)
0.1 4.8 GO:0030332 cyclin binding(GO:0030332)
1.6 4.7 GO:0070052 collagen V binding(GO:0070052)
0.5 4.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 4.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.4 4.2 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.2 4.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)