Motif ID: Irf3

Z-value: 0.817


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.321.1e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_36409719 2.268 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr16_+_35938972 2.050 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr2_-_105399286 1.895 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr16_+_35938470 1.857 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr16_-_35939082 1.845 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr14_-_65833963 1.739 ENSMUST00000022613.9
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr1_+_61638819 1.474 ENSMUST00000138768.1
ENSMUST00000075374.3
Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr13_+_74639866 1.392 ENSMUST00000169114.1
Erap1
endoplasmic reticulum aminopeptidase 1
chr14_+_14012491 1.358 ENSMUST00000022257.2
Atxn7
ataxin 7
chr5_-_137116177 1.292 ENSMUST00000054384.5
ENSMUST00000152207.1
Trim56

tripartite motif-containing 56

chr18_-_32559914 1.193 ENSMUST00000174000.1
ENSMUST00000174459.1
Gypc

glycophorin C

chr3_+_81932601 1.063 ENSMUST00000029649.2
Ctso
cathepsin O
chr8_-_80739497 1.030 ENSMUST00000043359.8
Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr2_-_51934644 1.017 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr6_-_39118211 0.936 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr11_+_119393060 0.935 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr16_-_19706365 0.845 ENSMUST00000081880.5
Lamp3
lysosomal-associated membrane protein 3
chr7_-_116198487 0.841 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr17_+_75178797 0.824 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chrX_+_68678712 0.769 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
Fmr1



fragile X mental retardation syndrome 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.8 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.6 1.9 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.1 1.8 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 1.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.7 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.1 1.5 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 1.4 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.2 1.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.2 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 1.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 1.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 1.0 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 0.8 GO:0009597 detection of virus(GO:0009597)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.7 GO:0055070 copper ion homeostasis(GO:0055070)
0.2 0.6 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 0.6 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 0.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.6 GO:0016082 synaptic vesicle priming(GO:0016082)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0031519 PcG protein complex(GO:0031519)
0.2 2.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.6 1.9 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.3 1.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 1.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 1.4 GO:0030914 STAGA complex(GO:0030914)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 1.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 1.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 0.8 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.6 GO:0097452 GAIT complex(GO:0097452)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.5 GO:0071203 WASH complex(GO:0071203)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.4 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 1.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.4 1.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 1.5 GO:0050436 microfibril binding(GO:0050436)
0.3 1.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 1.4 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.8 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.6 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0005507 copper ion binding(GO:0005507)
0.1 0.4 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)