Motif ID: Irf3

Z-value: 0.817


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.321.1e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_36409719 2.268 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr16_+_35938972 2.050 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr2_-_105399286 1.895 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr16_+_35938470 1.857 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr16_-_35939082 1.845 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr14_-_65833963 1.739 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr1_+_61638819 1.474 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr13_+_74639866 1.392 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr14_+_14012491 1.358 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr5_-_137116177 1.292 ENSMUST00000054384.5
ENSMUST00000152207.1
 Trim56

tripartite motif-containing 56

chr18_-_32559914 1.193 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr3_+_81932601 1.063 ENSMUST00000029649.2
 Ctso
cathepsin O
chr8_-_80739497 1.030 ENSMUST00000043359.8
 Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr2_-_51934644 1.017 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr6_-_39118211 0.936 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr11_+_119393060 0.935 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr16_-_19706365 0.845 ENSMUST00000081880.5
 Lamp3
lysosomal-associated membrane protein 3
chr7_-_116198487 0.841 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr17_+_75178797 0.824 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chrX_+_68678712 0.769 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr15_+_79892397 0.750 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr17_+_75178911 0.723 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr19_+_43752996 0.706 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr15_+_79892436 0.630 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chrX_-_38576189 0.618 ENSMUST00000115118.1
 Cul4b
cullin 4B
chr15_+_32920723 0.617 ENSMUST00000022871.5
 Sdc2
syndecan 2
chrX_+_68678541 0.616 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr11_+_20647149 0.601 ENSMUST00000109585.1
 Sertad2
SERTA domain containing 2
chr7_-_102565425 0.590 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chrX_-_38576166 0.588 ENSMUST00000050083.5
 Cul4b
cullin 4B
chr6_-_23839137 0.565 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr2_-_126933229 0.564 ENSMUST00000028844.4
 Sppl2a
signal peptide peptidase like 2A
chr7_-_45136231 0.555 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr4_-_40239700 0.547 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_173276144 0.527 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr2_-_51934943 0.511 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chr3_+_142560351 0.490 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr10_+_83543941 0.488 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene
chr3_+_142560108 0.481 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chrX_+_68678624 0.478 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr2_-_145935014 0.468 ENSMUST00000001818.4
 Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr7_-_104315455 0.456 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr11_+_58199556 0.452 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr6_-_56797761 0.435 ENSMUST00000114321.1
 Kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr3_+_142530329 0.422 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr6_-_34317442 0.420 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chrX_+_101429555 0.415 ENSMUST00000033673.6
 Nono
non-POU-domain-containing, octamer binding protein
chr10_-_87493651 0.408 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr2_+_152962485 0.403 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr11_+_109362771 0.358 ENSMUST00000020930.7
ENSMUST00000106702.3
 Gna13

guanine nucleotide binding protein, alpha 13

chr17_+_21008921 0.355 ENSMUST00000088811.5
 Zfp160
zinc finger protein 160
chr7_-_100514800 0.326 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr3_+_142560052 0.324 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr1_-_37890333 0.323 ENSMUST00000139725.1
ENSMUST00000027257.8
 Mitd1

MIT, microtubule interacting and transport, domain containing 1

chr6_-_56797637 0.313 ENSMUST00000114323.1
 Kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr9_+_108508005 0.313 ENSMUST00000006838.8
ENSMUST00000134939.1
 Qars

glutaminyl-tRNA synthetase

chr18_+_23989632 0.282 ENSMUST00000074941.7
 Zfp35
zinc finger protein 35
chr9_-_35176039 0.270 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr17_-_34187219 0.267 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr15_-_39112642 0.219 ENSMUST00000022908.8
 Slc25a32
solute carrier family 25, member 32
chr6_-_125231772 0.214 ENSMUST00000043422.7
 Tapbpl
TAP binding protein-like
chr4_-_40239779 0.209 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_-_48871408 0.197 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr2_-_156857946 0.175 ENSMUST00000099141.2
 4930518I15Rik
RIKEN cDNA 4930518I15 gene
chr11_-_48871344 0.132 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr2_+_122147680 0.119 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr5_-_110770132 0.117 ENSMUST00000112433.1
 Ep400
E1A binding protein p400
chr17_-_36020525 0.100 ENSMUST00000174063.1
ENSMUST00000113760.3
 H2-T24

histocompatibility 2, T region locus 24

chr7_-_141266415 0.087 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
 Irf7


interferon regulatory factor 7


chr8_-_70766654 0.085 ENSMUST00000034299.5
 Ifi30
interferon gamma inducible protein 30
chr11_-_49064202 0.074 ENSMUST00000046745.6
 Tgtp2
T cell specific GTPase 2
chr2_+_167062934 0.058 ENSMUST00000125674.1
 1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr7_-_104353328 0.051 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr16_+_23609895 0.046 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr5_+_123252087 0.039 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chr5_+_29434664 0.030 ENSMUST00000001611.9
 Nom1
nucleolar protein with MIF4G domain 1
chr19_-_43752924 0.013 ENSMUST00000045562.5
 Cox15
cytochrome c oxidase assembly protein 15
chr11_+_72301613 0.012 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr17_+_34187789 0.011 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr14_-_55591077 0.008 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr2_-_62646146 0.002 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.5 3.8 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 1.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 1.4 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.2 0.2 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.2 1.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 0.8 GO:0009597 detection of virus(GO:0009597)
0.2 0.6 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 1.0 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.4 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 0.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.1 0.6 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 1.7 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.1 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.2 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 0.1 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.1 1.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 1.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 1.5 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.4 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 1.8 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.5 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.7 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.6 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.2 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.1 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0 0.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.5 GO:0007032 endosome organization(GO:0007032)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.5 1.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.3 1.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 0.8 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.2 2.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.2 1.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.6 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.6 GO:0097452 GAIT complex(GO:0097452)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.4 GO:0030914 STAGA complex(GO:0030914)
0.1 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.5 GO:0071203 WASH complex(GO:0071203)
0.0 2.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:1990462 omegasome(GO:1990462)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 1.5 GO:0050436 microfibril binding(GO:0050436)
0.4 1.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 1.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 4.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 1.4 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.4 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.6 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.8 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.5 GO:0005507 copper ion binding(GO:0005507)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)