Motif ID: Irf4

Z-value: 0.595


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_90537242 1.855 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr3_+_90537306 1.797 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chrX_-_134161928 1.297 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr11_-_77894096 1.158 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr1_-_163313661 1.134 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr19_-_58454580 1.101 ENSMUST00000129100.1
ENSMUST00000123957.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr19_-_58455161 0.915 ENSMUST00000135730.1
ENSMUST00000152507.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr19_-_58455398 0.788 ENSMUST00000026076.7
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr14_-_122465677 0.776 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr6_+_82041623 0.750 ENSMUST00000042974.8
 Eva1a
eva-1 homolog A (C. elegans)
chr11_+_119393060 0.743 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr3_-_142395661 0.660 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
 Pdlim5



PDZ and LIM domain 5



chr2_-_127788854 0.646 ENSMUST00000028857.7
ENSMUST00000110357.1
 Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chr7_+_58658181 0.629 ENSMUST00000168747.1
 Atp10a
ATPase, class V, type 10A
chr11_-_101551837 0.621 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr19_-_24225015 0.601 ENSMUST00000099558.4
 Tjp2
tight junction protein 2
chr6_+_71282280 0.573 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr5_+_28165690 0.569 ENSMUST00000036177.7
 En2
engrailed 2
chr9_-_114564315 0.569 ENSMUST00000111816.2
 Trim71
tripartite motif-containing 71
chr7_-_65370908 0.567 ENSMUST00000032729.6
 Tjp1
tight junction protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0051592 response to calcium ion(GO:0051592)
0.4 1.2 GO:0006553 lysine metabolic process(GO:0006553)
0.1 1.1 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.8 GO:0033504 floor plate development(GO:0033504)
0.1 0.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 0.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 0.6 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.6 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.6 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.6 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.6 GO:0015914 phospholipid transport(GO:0015914)
0.2 0.5 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.2 0.5 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.5 GO:0001907 killing by symbiont of host cells(GO:0001907) induction of programmed cell death(GO:0012502) disruption by symbiont of host cell(GO:0044004) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.5 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.5 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.4 GO:0002184 cytoplasmic translational termination(GO:0002184)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.6 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.4 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.4 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.1 0.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 0.3 GO:1990357 terminal web(GO:1990357)
0.1 0.2 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0005178 integrin binding(GO:0005178)
0.3 1.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.7 GO:0042805 actinin binding(GO:0042805)
0.0 0.6 GO:0035198 miRNA binding(GO:0035198)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.5 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.5 GO:0016594 glycine binding(GO:0016594)
0.0 0.5 GO:0045502 dynein binding(GO:0045502)
0.0 0.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.3 GO:0002135 CTP binding(GO:0002135)