Motif ID: Irf5_Irf6

Z-value: 0.575

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6



Activity profile for motif Irf5_Irf6.

activity profile for motif Irf5_Irf6


Sorted Z-values histogram for motif Irf5_Irf6

Sorted Z-values for motif Irf5_Irf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_142395661 2.187 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
 Pdlim5



PDZ and LIM domain 5



chr1_-_163313661 2.018 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr2_-_69586021 1.657 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
 Lrp2


low density lipoprotein receptor-related protein 2


chr16_-_35939082 1.487 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr16_+_35938972 1.475 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr11_-_86201144 1.241 ENSMUST00000044423.3
 Brip1
BRCA1 interacting protein C-terminal helicase 1
chr19_+_55741810 1.224 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr9_+_45042425 1.224 ENSMUST00000034600.4
 Mpzl2
myelin protein zero-like 2
chr11_+_88999376 1.108 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
 Trim25


tripartite motif-containing 25


chr7_+_128523576 1.020 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr17_+_23679363 1.012 ENSMUST00000024699.2
 Cldn6
claudin 6
chr5_+_139543889 1.010 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr12_-_73113407 0.894 ENSMUST00000175693.1
 Six4
sine oculis-related homeobox 4
chr7_-_65370908 0.876 ENSMUST00000032729.6
 Tjp1
tight junction protein 1
chr5_+_92809372 0.820 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr17_-_78882508 0.715 ENSMUST00000024884.4
 Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr6_+_57580992 0.703 ENSMUST00000031817.8
 Herc6
hect domain and RLD 6
chr16_+_35938470 0.631 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_-_141010759 0.564 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr5_-_99978914 0.517 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
 Hnrnpd




heterogeneous nuclear ribonucleoprotein D





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 2.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 2.0 GO:0048664 neuron fate determination(GO:0048664)
0.2 1.7 GO:0045056 transcytosis(GO:0045056)
0.1 1.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 1.5 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 1.5 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.2 1.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 1.0 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.3 0.9 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) skeletal muscle fiber differentiation(GO:0098528)
0.1 0.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 0.7 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.7 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.2 0.5 GO:0045472 response to ether(GO:0045472)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.1 0.4 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0030018 Z disc(GO:0030018)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.1 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.5 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.2 GO:0042805 actinin binding(GO:0042805)
0.1 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.3 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.1 1.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 1.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.7 GO:0030332 cyclin binding(GO:0030332)
0.1 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.3 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.2 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)