Motif ID: Irf5_Irf6

Z-value: 0.575

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6






Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_142395661 2.187 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chr1_-_163313661 2.018 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr2_-_69586021 1.657 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2


low density lipoprotein receptor-related protein 2


chr16_-_35939082 1.487 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr16_+_35938972 1.475 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr11_-_86201144 1.241 ENSMUST00000044423.3
Brip1
BRCA1 interacting protein C-terminal helicase 1
chr19_+_55741810 1.224 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr9_+_45042425 1.224 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr11_+_88999376 1.108 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr7_+_128523576 1.020 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr17_+_23679363 1.012 ENSMUST00000024699.2
Cldn6
claudin 6
chr5_+_139543889 1.010 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr12_-_73113407 0.894 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4
chr7_-_65370908 0.876 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr5_+_92809372 0.820 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr17_-_78882508 0.715 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr6_+_57580992 0.703 ENSMUST00000031817.8
Herc6
hect domain and RLD 6
chr16_+_35938470 0.631 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_-_141010759 0.564 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr5_-_99978914 0.517 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
Hnrnpd




heterogeneous nuclear ribonucleoprotein D




chr4_+_108460000 0.503 ENSMUST00000097925.2
Zcchc11
zinc finger, CCHC domain containing 11
chr15_+_96287518 0.497 ENSMUST00000134985.2
ENSMUST00000096250.4
Arid2

AT rich interactive domain 2 (ARID, RFX-like)

chrX_+_77511002 0.442 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chr9_+_57072024 0.436 ENSMUST00000169879.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr11_+_60699758 0.428 ENSMUST00000108719.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr2_-_51934644 0.383 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr16_-_5255923 0.357 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr9_-_123851855 0.352 ENSMUST00000184082.1
ENSMUST00000167595.2
Fyco1

FYVE and coiled-coil domain containing 1

chr9_-_14381242 0.349 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr6_-_39118211 0.339 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_-_91646906 0.294 ENSMUST00000120450.1
ENSMUST00000023684.7
Gart

phosphoribosylglycinamide formyltransferase

chrX_-_95444789 0.280 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr11_+_60699718 0.277 ENSMUST00000052346.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr6_-_13608011 0.266 ENSMUST00000031554.2
Tmem168
transmembrane protein 168
chrX_+_37126777 0.265 ENSMUST00000016553.4
Nkap
NFKB activating protein
chr15_+_9436028 0.255 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr11_+_69966896 0.250 ENSMUST00000151515.1
Cldn7
claudin 7
chr11_+_29130733 0.250 ENSMUST00000020756.8
Pnpt1
polyribonucleotide nucleotidyltransferase 1
chr1_+_52119438 0.249 ENSMUST00000070968.7
Stat1
signal transducer and activator of transcription 1
chr4_-_58911902 0.223 ENSMUST00000134848.1
ENSMUST00000107557.2
ENSMUST00000149301.1
AI314180


expressed sequence AI314180


chr15_+_99126513 0.218 ENSMUST00000063517.4
Spats2
spermatogenesis associated, serine-rich 2
chr9_+_95954744 0.204 ENSMUST00000034981.7
Xrn1
5'-3' exoribonuclease 1
chr3_+_135438722 0.188 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr4_-_40239779 0.173 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_77170592 0.164 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr3_+_142496924 0.163 ENSMUST00000090127.2
Gbp5
guanylate binding protein 5
chr6_-_87838671 0.155 ENSMUST00000089497.4
Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr7_+_83755904 0.131 ENSMUST00000051522.8
ENSMUST00000042280.7
Gm7964

predicted gene 7964

chr4_-_46536096 0.129 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr17_+_34203527 0.124 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_-_34862473 0.124 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb


complement factor B


chr8_+_71597648 0.110 ENSMUST00000143662.1
Fam129c
family with sequence similarity 129, member C
chr17_-_32189457 0.098 ENSMUST00000087721.3
ENSMUST00000162117.1
Ephx3

epoxide hydrolase 3

chr6_-_124911636 0.097 ENSMUST00000032217.1
Lag3
lymphocyte-activation gene 3
chr4_-_40239700 0.095 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_-_31950170 0.070 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chrX_-_101222426 0.065 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr5_+_99979061 0.060 ENSMUST00000046721.1
4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr1_+_175632169 0.057 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr16_-_55838827 0.047 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr7_-_44375006 0.045 ENSMUST00000107933.1
1700008O03Rik
RIKEN cDNA 1700008O03 gene
chr1_-_105356658 0.028 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr1_-_184732616 0.017 ENSMUST00000048572.6
Hlx
H2.0-like homeobox
chr11_-_78984946 0.008 ENSMUST00000108268.3
Lgals9
lectin, galactose binding, soluble 9
chr11_-_78984831 0.002 ENSMUST00000073001.4
ENSMUST00000108269.3
Lgals9

lectin, galactose binding, soluble 9


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 0.9 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) skeletal muscle fiber differentiation(GO:0098528)
0.2 0.5 GO:0045472 response to ether(GO:0045472)
0.2 1.7 GO:0045056 transcytosis(GO:0045056)
0.2 2.0 GO:0048664 neuron fate determination(GO:0048664)
0.2 1.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.4 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 1.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.7 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 0.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.7 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.1 0.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.3 GO:0009597 detection of virus(GO:0009597)
0.1 0.1 GO:2000642 negative regulation of vacuolar transport(GO:1903336) negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 2.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.2 GO:0060333 regulation of macrophage fusion(GO:0034239) interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 0.3 GO:0046654 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.2 GO:0000389 generation of catalytic spliceosome for second transesterification step(GO:0000350) mRNA 3'-splice site recognition(GO:0000389)
0.0 0.3 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 1.0 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.0 1.5 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 0.2 GO:0032621 interleukin-18 production(GO:0032621) positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.3 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0019441 tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189)
0.0 0.2 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028) histone mRNA catabolic process(GO:0071044)
0.0 1.5 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 3.2 GO:0030018 Z disc(GO:0030018)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.5 GO:0090544 BAF-type complex(GO:0090544)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.2 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.3 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 2.2 GO:0042805 actinin binding(GO:0042805)
0.1 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.2 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 1.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.7 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)