Motif ID: Irx5

Z-value: 0.402


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.509.4e-03Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 1.477 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_99759658 1.009 ENSMUST00000056085.4
 Csl
citrate synthase like
chr7_-_114927726 0.909 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr2_+_25180737 0.635 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr2_-_85035487 0.631 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr1_-_78968079 0.560 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr8_+_85171322 0.531 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr16_+_30065333 0.446 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr9_-_78378725 0.424 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr5_-_88675190 0.421 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr17_+_50698525 0.420 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr10_+_88146992 0.359 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr12_+_55598917 0.358 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr13_+_24943144 0.356 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr17_+_7925990 0.351 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr5_+_48242549 0.345 ENSMUST00000172493.1
 Slit2
slit homolog 2 (Drosophila)
chr2_-_101621033 0.323 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr3_+_95124476 0.316 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr4_+_148039097 0.299 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr10_-_88146867 0.287 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 0.6 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 0.6 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 0.4 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.4 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.3 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.3 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.2 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.1 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.1 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.4 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.4 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)