Motif ID: Irx5

Z-value: 0.402


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.509.4e-03Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 1.477 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_99759658 1.009 ENSMUST00000056085.4
 Csl
citrate synthase like
chr7_-_114927726 0.909 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr2_+_25180737 0.635 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr2_-_85035487 0.631 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr1_-_78968079 0.560 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr8_+_85171322 0.531 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr16_+_30065333 0.446 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr9_-_78378725 0.424 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr5_-_88675190 0.421 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr17_+_50698525 0.420 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr10_+_88146992 0.359 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr12_+_55598917 0.358 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr13_+_24943144 0.356 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr17_+_7925990 0.351 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr5_+_48242549 0.345 ENSMUST00000172493.1
 Slit2
slit homolog 2 (Drosophila)
chr2_-_101621033 0.323 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr3_+_95124476 0.316 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr4_+_148039097 0.299 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr10_-_88146867 0.287 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr10_+_11609256 0.286 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr6_+_50110837 0.281 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr3_+_124321031 0.281 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr10_+_3872667 0.243 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr14_+_48446340 0.241 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr8_-_107263248 0.225 ENSMUST00000080443.6
 Rps18-ps3
ribosomal protein S18, pseudogene 3
chr9_-_7835255 0.222 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr2_-_106970391 0.214 ENSMUST00000093883.3
 Arl14ep
ADP-ribosylation factor-like 14 effector protein
chr16_-_56024628 0.200 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr14_-_14120904 0.193 ENSMUST00000022256.3
 Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr4_+_43632185 0.190 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr12_-_108893197 0.190 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr4_-_49521036 0.188 ENSMUST00000057829.3
 Mrpl50
mitochondrial ribosomal protein L50
chr4_+_6365650 0.187 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
 Sdcbp




syndecan binding protein




chr11_-_28339867 0.185 ENSMUST00000042595.6
 Gm6685
predicted pseudogene 6685
chr11_-_68927049 0.185 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr1_-_169969143 0.174 ENSMUST00000027989.6
ENSMUST00000111353.3
 Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

chr4_-_59783800 0.147 ENSMUST00000107526.1
ENSMUST00000095063.4
 Inip

INTS3 and NABP interacting protein

chr8_+_4240105 0.134 ENSMUST00000110994.1
ENSMUST00000110995.1
 Map2k7

mitogen-activated protein kinase kinase 7

chr12_-_85288419 0.130 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chr11_-_49712674 0.129 ENSMUST00000020624.6
ENSMUST00000145353.1
 Cnot6

CCR4-NOT transcription complex, subunit 6

chr2_-_151009364 0.120 ENSMUST00000109896.1
 Ninl
ninein-like
chr4_-_43653560 0.117 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr2_+_104027823 0.112 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
 Fbxo3


F-box protein 3


chr3_-_158031705 0.112 ENSMUST00000072875.8
 Srsf11
serine/arginine-rich splicing factor 11
chr4_-_43653542 0.105 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr12_+_85288591 0.105 ENSMUST00000059341.4
 Zc2hc1c
zinc finger, C2HC-type containing 1C
chr12_-_99393010 0.104 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr2_+_104027721 0.104 ENSMUST00000028603.3
 Fbxo3
F-box protein 3
chrX_+_135742686 0.103 ENSMUST00000113144.1
ENSMUST00000113147.1
ENSMUST00000113145.1
ENSMUST00000096321.2
 Gprasp1


Armcx5
G protein-coupled receptor associated sorting protein 1


armadillo repeat containing, X-linked 5
chr11_-_69579320 0.101 ENSMUST00000048139.5
 Wrap53
WD repeat containing, antisense to Trp53
chr16_+_33185045 0.097 ENSMUST00000039733.8
 Osbpl11
oxysterol binding protein-like 11
chr19_-_8713862 0.085 ENSMUST00000010239.4
 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr19_-_16780822 0.061 ENSMUST00000068156.6
 Vps13a
vacuolar protein sorting 13A (yeast)
chr17_-_87025353 0.060 ENSMUST00000024957.6
 Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr17_+_21657582 0.058 ENSMUST00000039726.7
 3110052M02Rik
RIKEN cDNA 3110052M02 gene
chr4_-_89311021 0.054 ENSMUST00000097981.4
 Cdkn2b
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr18_+_76944384 0.047 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
 Hdhd2



haloacid dehalogenase-like hydrolase domain containing 2



chr2_-_73625731 0.046 ENSMUST00000070579.6
 Chn1
chimerin (chimaerin) 1
chr11_-_69395333 0.041 ENSMUST00000108660.1
ENSMUST00000051620.4
 Cyb5d1

cytochrome b5 domain containing 1

chr12_+_71048338 0.022 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr11_-_102469839 0.021 ENSMUST00000103086.3
 Itga2b
integrin alpha 2b
chr1_+_165301863 0.008 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr14_-_19977040 0.006 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr12_+_69893105 0.000 ENSMUST00000021466.8
 Atl1
atlastin GTPase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.2 1.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.4 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.4 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.3 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.2 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.6 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.1 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.3 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.1 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.4 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)