Motif ID: Irx6_Irx2_Irx3

Z-value: 0.885

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72628831_72628971-0.526.8e-03Click!
Irx6mm10_v2_chr8_+_92674289_92674289-0.491.1e-02Click!
Irx3mm10_v2_chr8_-_91801547_91801560-0.452.0e-02Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 5.451 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr2_-_67433181 3.029 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr10_-_125328957 2.915 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr16_+_17146937 2.384 ENSMUST00000115706.1
ENSMUST00000069064.4
 Ydjc

YdjC homolog (bacterial)

chr13_+_49504774 2.206 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr8_+_36489191 2.184 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr10_+_61171954 2.012 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr6_+_149130170 2.003 ENSMUST00000087348.3
 Gm10203
predicted gene 10203
chr7_-_103827922 1.734 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr9_-_112232449 1.617 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr13_+_76579670 1.570 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr14_-_30353468 1.535 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr2_-_119271202 1.512 ENSMUST00000037360.7
 Rhov
ras homolog gene family, member V
chr2_-_169405435 1.475 ENSMUST00000131509.1
 4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr8_+_129118043 1.429 ENSMUST00000108744.1
 1700008F21Rik
RIKEN cDNA 1700008F21 gene
chr2_-_98667264 1.312 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr3_-_87263518 1.257 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr7_+_19212521 1.254 ENSMUST00000060225.4
 Gpr4
G protein-coupled receptor 4
chr6_-_48708206 1.142 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr5_-_137601043 1.118 ENSMUST00000037620.7
ENSMUST00000154708.1
 Mospd3

motile sperm domain containing 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 2.9 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 2.3 GO:0008033 tRNA processing(GO:0008033)
0.1 2.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.7 GO:0048515 spermatid differentiation(GO:0048515)
0.5 1.5 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.4 1.3 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0 1.0 GO:0045214 sarcomere organization(GO:0045214)
0.3 0.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 0.9 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 0.9 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.2 0.8 GO:1900272 negative regulation of long-term synaptic potentiation(GO:1900272)
0.2 0.8 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 0.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.7 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 0.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.4 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.2 1.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.3 0.9 GO:0072534 perineuronal net(GO:0072534)
0.1 0.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.2 0.7 GO:0043512 inhibin A complex(GO:0043512)
0.2 0.5 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.5 GO:0000801 central element(GO:0000801)
0.0 0.5 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.4 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 0.3 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)
0.0 0.3 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.7 2.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 2.4 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 2.3 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.7 2.2 GO:0070052 collagen V binding(GO:0070052)
0.3 1.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.3 1.5 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.3 0.9 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.9 GO:0046625 sphingolipid binding(GO:0046625)
0.2 0.8 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 0.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.5 GO:0019841 retinol binding(GO:0019841)
0.1 0.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)