Motif ID: Isl2

Z-value: 0.654


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 170 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_77166545 2.055 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chr1_+_12718496 1.888 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr12_-_10900296 1.599 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr1_-_163289214 1.582 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr9_-_100506844 1.574 ENSMUST00000112874.3
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr11_-_17953861 1.488 ENSMUST00000076661.6
Etaa1
Ewing's tumor-associated antigen 1
chr17_-_48432723 1.480 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr4_+_136172367 1.379 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr14_+_27039001 1.362 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr9_+_35423582 1.337 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr1_-_128102412 1.319 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr9_+_72806874 1.196 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr8_-_61902669 1.174 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chrX_-_60893430 1.168 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr3_-_79841729 1.162 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr10_-_13324160 1.159 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr2_+_109280738 1.158 ENSMUST00000028527.7
Kif18a
kinesin family member 18A
chr4_+_3940747 1.158 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr17_+_17402672 1.146 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr13_+_104229366 1.098 ENSMUST00000022227.6
Cenpk
centromere protein K

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.7 2.0 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.5 1.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 1.6 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.1 1.6 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.5 GO:0080111 DNA demethylation(GO:0080111)
0.2 1.4 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.4 1.3 GO:0036292 DNA rewinding(GO:0036292)
0.2 1.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.3 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 1.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.2 GO:0007530 sex determination(GO:0007530)
0.1 1.2 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 1.1 GO:0006825 copper ion transport(GO:0006825)
0.0 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 1.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 1.0 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.9 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.0 2.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.5 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1 0.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.4 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.4 GO:0012505 endomembrane system(GO:0012505)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 1.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 1.6 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 1.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.5 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.5 1.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.3 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.3 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.2 GO:0051010 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) microtubule plus-end binding(GO:0051010)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.1 1.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.1 0.8 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.2 0.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)