Motif ID: Klf1

Z-value: 3.526


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.413.8e-02Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103813913 22.239 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr7_-_46179929 17.580 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr6_+_5725639 17.030 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr5_-_139325616 16.756 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr7_+_44310213 15.232 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr15_+_83791939 14.975 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr11_+_104231390 14.476 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr2_-_162661075 14.034 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr10_-_81025521 13.918 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr11_+_104231515 13.697 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_104231465 13.500 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr7_-_103827922 13.464 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr6_+_103510874 11.992 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr10_+_127078886 11.959 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr8_+_84723003 11.313 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr14_+_70554056 11.081 ENSMUST00000022691.7
 Hr
hairless
chr12_-_4841583 10.631 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr2_+_92599671 10.461 ENSMUST00000065797.6
 Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr5_+_117781017 10.411 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr11_-_55033398 10.246 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 531 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 56.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.6 38.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.1 29.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.8 25.5 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.2 22.2 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.8 19.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.3 19.5 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.7 16.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.2 15.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
5.1 15.2 GO:0046959 habituation(GO:0046959)
0.7 14.5 GO:0016082 synaptic vesicle priming(GO:0016082)
0.6 14.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 13.8 GO:0050890 cognition(GO:0050890)
0.4 13.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.6 12.9 GO:0048266 behavioral response to pain(GO:0048266)
0.5 12.8 GO:0010043 response to zinc ion(GO:0010043)
2.1 12.5 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
1.2 12.3 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.8 12.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.9 12.0 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 64.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 61.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 47.3 GO:0034704 calcium channel complex(GO:0034704)
4.7 46.9 GO:0045298 tubulin complex(GO:0045298)
8.9 35.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 27.0 GO:0008021 synaptic vesicle(GO:0008021)
1.3 21.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 19.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 19.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 19.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.2 18.7 GO:0031225 anchored component of membrane(GO:0031225)
0.6 16.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 15.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.5 14.6 GO:0097440 apical dendrite(GO:0097440)
0.6 14.4 GO:0071565 nBAF complex(GO:0071565)
0.3 14.3 GO:0031941 filamentous actin(GO:0031941)
0.8 13.6 GO:0031083 BLOC-1 complex(GO:0031083)
0.8 13.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 13.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 13.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 374 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 48.0 GO:0005096 GTPase activator activity(GO:0005096)
2.0 44.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 36.8 GO:0003924 GTPase activity(GO:0003924)
8.9 35.7 GO:0031720 haptoglobin binding(GO:0031720)
0.4 27.4 GO:0019905 syntaxin binding(GO:0019905)
0.4 25.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.8 23.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
5.2 20.8 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.8 19.9 GO:0038191 neuropilin binding(GO:0038191)
0.4 19.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 17.9 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
1.0 17.8 GO:0050811 GABA receptor binding(GO:0050811)
3.5 17.6 GO:0045503 dynein light chain binding(GO:0045503)
0.7 17.6 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
1.1 16.7 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.4 16.6 GO:0001540 beta-amyloid binding(GO:0001540)
1.3 16.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 16.1 GO:0030507 spectrin binding(GO:0030507)
0.7 15.9 GO:0003785 actin monomer binding(GO:0003785)
1.1 15.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)