Motif ID: Klf12_Klf14_Sp4

Z-value: 0.626

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp4mm10_v2_chr12_-_118301429_1183014580.038.7e-01Click!
Klf12mm10_v2_chr14_-_100149764_1001497640.029.4e-01Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78322965 2.344 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr5_-_99252839 1.615 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr9_+_80165079 1.325 ENSMUST00000184480.1
 Myo6
myosin VI
chr10_-_59951753 1.253 ENSMUST00000020308.3
 Ddit4
DNA-damage-inducible transcript 4
chr9_+_80165013 1.243 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr2_+_172345565 1.184 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr13_+_92611119 1.178 ENSMUST00000049488.7
 Serinc5
serine incorporator 5
chr9_-_21918089 1.165 ENSMUST00000128442.1
ENSMUST00000119055.1
ENSMUST00000122211.1
ENSMUST00000115351.3
 Rab3d



RAB3D, member RAS oncogene family



chr13_-_49215978 1.084 ENSMUST00000048946.6
 1110007C09Rik
RIKEN cDNA 1110007C09 gene
chr2_-_134644079 1.036 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr5_+_37028329 1.030 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr2_-_30474199 0.960 ENSMUST00000065134.2
 Ier5l
immediate early response 5-like
chr5_-_31241215 0.927 ENSMUST00000068997.3
 Gm9970
predicted gene 9970
chr17_-_56716788 0.898 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr4_-_120287349 0.880 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr5_-_109558957 0.873 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr4_-_129121699 0.840 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr6_-_85374606 0.830 ENSMUST00000060837.7
 Rab11fip5
RAB11 family interacting protein 5 (class I)
chr17_+_46161111 0.826 ENSMUST00000166563.1
 Gtpbp2
GTP binding protein 2
chr7_-_63938862 0.790 ENSMUST00000063694.8
 Klf13
Kruppel-like factor 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 393 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 2.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.7 2.1 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 1.3 GO:0045820 negative regulation of glycolytic process(GO:0045820)
0.2 1.2 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.3 1.1 GO:0009597 detection of virus(GO:0009597)
0.1 1.1 GO:2000821 regulation of grooming behavior(GO:2000821)
0.2 1.0 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 1.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 0.9 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.9 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 0.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 0.8 GO:1905049 negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.2 0.8 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 0.8 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.1 0.8 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.8 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.8 GO:0051865 protein autoubiquitination(GO:0051865)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 2.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.8 GO:0000786 nucleosome(GO:0000786)
0.4 1.6 GO:0045098 type III intermediate filament(GO:0045098)
0.0 1.5 GO:0032994 protein-lipid complex(GO:0032994)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0005776 autophagosome(GO:0005776)
0.1 1.1 GO:0042588 zymogen granule(GO:0042588)
0.0 1.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 1.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.0 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.9 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0051015 actin filament binding(GO:0051015)
0.0 2.4 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.4 2.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 2.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.4 GO:0031489 myosin V binding(GO:0031489)
0.0 1.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 1.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.1 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.0 1.1 GO:0005125 cytokine activity(GO:0005125)
0.2 1.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.3 0.9 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.2 0.8 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.8 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.7 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.7 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 0.6 GO:0035175 histone kinase activity (H3-S10 specific)(GO:0035175)