Motif ID: Klf16_Sp8

Z-value: 1.114

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf16mm10_v2_chr10_-_80577285_80577327-0.572.2e-03Click!
Sp8mm10_v2_chr12_+_118846329_1188463290.544.5e-03Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_38107490 7.354 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr9_-_119578981 6.661 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_-_144939823 6.628 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr18_+_82914632 6.560 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr8_+_105518736 6.473 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr17_-_32166879 6.175 ENSMUST00000087723.3
 Notch3
notch 3
chr5_-_144358103 6.106 ENSMUST00000055190.7
 Baiap2l1
BAI1-associated protein 2-like 1
chr17_-_70851189 5.846 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr2_+_164562579 5.553 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr15_+_25622525 5.528 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr12_+_103314944 5.255 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chrX_-_106485214 5.047 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr18_+_49979427 4.992 ENSMUST00000148989.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr4_-_117133953 4.941 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr19_+_55741810 4.906 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr12_+_17690793 4.818 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr18_+_49979514 4.809 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr9_+_7764041 4.807 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123
chr19_+_6084983 4.747 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr18_+_67289235 4.654 ENSMUST00000025403.6
 Impa2
inositol (myo)-1(or 4)-monophosphatase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 17.0 GO:0038092 nodal signaling pathway(GO:0038092)
1.2 16.0 GO:0032252 secretory granule localization(GO:0032252)
2.3 15.8 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.5 14.6 GO:0006270 DNA replication initiation(GO:0006270)
0.1 13.8 GO:0051028 mRNA transport(GO:0051028)
0.4 12.9 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.7 11.7 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 10.5 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.0 9.9 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.8 9.9 GO:0044458 motile cilium assembly(GO:0044458)
0.5 9.0 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.3 9.0 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.6 8.9 GO:0051764 actin crosslink formation(GO:0051764)
2.9 8.7 GO:0048496 maintenance of organ identity(GO:0048496)
1.7 8.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.6 8.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
2.8 8.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.6 7.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 7.7 GO:0006284 base-excision repair(GO:0006284)
1.9 7.6 GO:0015888 thiamine transport(GO:0015888)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 381 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 70.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 64.7 GO:0005634 nucleus(GO:0005634)
0.0 50.5 GO:0005654 nucleoplasm(GO:0005654)
0.6 27.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 21.1 GO:0005681 spliceosomal complex(GO:0005681)
0.3 18.7 GO:0005844 polysome(GO:0005844)
0.1 15.9 GO:0000790 nuclear chromatin(GO:0000790)
0.3 15.0 GO:0000791 euchromatin(GO:0000791)
0.2 14.6 GO:0005643 nuclear pore(GO:0005643)
0.3 14.2 GO:0005876 spindle microtubule(GO:0005876)
1.2 13.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 12.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 12.8 GO:0016580 Sin3 complex(GO:0016580)
0.2 12.4 GO:0005814 centriole(GO:0005814)
1.3 9.3 GO:0000796 condensin complex(GO:0000796)
0.2 8.2 GO:0016592 mediator complex(GO:0016592)
1.4 8.1 GO:0061689 tricellular tight junction(GO:0061689)
0.8 7.8 GO:0001939 female pronucleus(GO:0001939)
0.1 7.2 GO:0043296 apical junction complex(GO:0043296)
0.4 7.1 GO:0010369 chromocenter(GO:0010369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 594 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 66.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 37.8 GO:0044822 poly(A) RNA binding(GO:0044822)
0.1 24.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 21.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.5 19.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.7 15.1 GO:0070410 co-SMAD binding(GO:0070410)
0.6 15.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 14.5 GO:0042393 histone binding(GO:0042393)
0.1 14.4 GO:0003682 chromatin binding(GO:0003682)
0.9 12.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 11.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 10.9 GO:0004386 helicase activity(GO:0004386)
0.2 10.7 GO:0001047 core promoter binding(GO:0001047)
0.5 10.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 10.0 GO:0070888 E-box binding(GO:0070888)
0.2 10.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 9.4 GO:0003729 mRNA binding(GO:0003729)
0.6 8.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.7 8.7 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.5 8.6 GO:0017166 vinculin binding(GO:0017166)