Motif ID: Klf4_Sp3

Z-value: 1.298

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp3mm10_v2_chr2_-_72980402_72980471-0.562.7e-03Click!
Klf4mm10_v2_chr4_-_55532453_555324850.301.4e-01Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105518736 7.540 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr4_+_124986430 4.542 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr5_+_128601106 4.172 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr8_-_92355764 3.985 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
 4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr17_-_70851189 3.842 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_38107490 3.730 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr4_-_117133953 3.559 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr12_+_17690793 3.543 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr8_-_91801948 3.534 ENSMUST00000175795.1
 Irx3
Iroquois related homeobox 3 (Drosophila)
chrX_-_106485214 3.321 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr13_+_54789377 3.229 ENSMUST00000026993.7
ENSMUST00000131692.2
ENSMUST00000163796.1
 Tspan17


tetraspanin 17


chr7_-_4752972 3.140 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr10_-_127534540 2.935 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chrX_-_106485367 2.860 ENSMUST00000140707.1
 Fndc3c1
fibronectin type III domain containing 3C1
chr19_+_55741810 2.837 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr7_-_34812677 2.762 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chrX_+_73639414 2.752 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr7_-_143460989 2.748 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_129239165 2.734 ENSMUST00000097873.3
 C77080
expressed sequence C77080
chr18_+_67289235 2.716 ENSMUST00000025403.6
 Impa2
inositol (myo)-1(or 4)-monophosphatase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.0 GO:0006412 translation(GO:0006412)
0.3 8.4 GO:0006270 DNA replication initiation(GO:0006270)
0.2 8.4 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 7.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.3 7.7 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.9 7.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.6 7.0 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.5 6.9 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.6 6.8 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.4 6.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.6 6.4 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.1 5.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.7 5.5 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030)
1.8 5.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.3 5.2 GO:0060375 regulation of mast cell differentiation(GO:0060375)
0.4 5.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2 5.1 GO:0007566 embryo implantation(GO:0007566)
1.2 5.0 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.3 4.8 GO:0045019 negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of nitric oxide metabolic process(GO:1904406)
0.9 4.7 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 413 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.4 GO:0005615 extracellular space(GO:0005615)
0.0 14.1 GO:0005739 mitochondrion(GO:0005739)
0.1 13.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 13.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 12.6 GO:0005667 transcription factor complex(GO:0005667)
0.2 10.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 9.6 GO:0016607 nuclear speck(GO:0016607)
0.2 8.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 8.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 8.1 GO:0000790 nuclear chromatin(GO:0000790)
0.1 7.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.9 7.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 6.5 GO:0030914 STAGA complex(GO:0030914)
0.1 6.5 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 6.0 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 6.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.0 5.8 GO:0061689 tricellular tight junction(GO:0061689)
0.5 5.8 GO:0030057 desmosome(GO:0030057)
0.6 5.6 GO:0005642 annulate lamellae(GO:0005642)
0.2 5.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 644 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 41.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 14.1 GO:0003682 chromatin binding(GO:0003682)
0.5 13.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 10.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 8.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 8.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 8.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 7.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 7.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 7.2 GO:0002039 p53 binding(GO:0002039)
1.4 7.1 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.5 7.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 6.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 6.5 GO:0070410 co-SMAD binding(GO:0070410)
0.3 6.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 6.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 6.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 6.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 5.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 5.7 GO:0070888 E-box binding(GO:0070888)