Motif ID: Klf7

Z-value: 0.457


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64122256_64122321-0.086.9e-01Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 2.473 ENSMUST00000055032.7
Kdm5d
lysine (K)-specific demethylase 5D
chr2_-_156312470 1.433 ENSMUST00000079125.6
Scand1
SCAN domain-containing 1
chr12_+_49382791 1.135 ENSMUST00000179669.1
Foxg1
forkhead box G1
chr12_+_49383007 1.067 ENSMUST00000021333.3
Foxg1
forkhead box G1
chr3_+_28263205 0.851 ENSMUST00000159236.2
Tnik
TRAF2 and NCK interacting kinase
chr6_-_88875035 0.824 ENSMUST00000145944.1
Podxl2
podocalyxin-like 2
chr15_+_30172570 0.732 ENSMUST00000081728.5
Ctnnd2
catenin (cadherin associated protein), delta 2
chr5_+_137761680 0.725 ENSMUST00000110983.2
ENSMUST00000031738.4
Tsc22d4

TSC22 domain family, member 4

chr4_+_107830958 0.718 ENSMUST00000106731.2
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr15_-_102722150 0.628 ENSMUST00000023818.3
Calcoco1
calcium binding and coiled coil domain 1
chr5_+_137778849 0.625 ENSMUST00000126126.1
ENSMUST00000031739.4
Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr15_-_102722120 0.608 ENSMUST00000171838.1
Calcoco1
calcium binding and coiled coil domain 1
chr7_-_28766469 0.577 ENSMUST00000085851.5
ENSMUST00000032815.4
Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr4_+_139622842 0.566 ENSMUST00000039818.9
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
chr2_+_172550991 0.566 ENSMUST00000170744.1
Tfap2c
transcription factor AP-2, gamma
chr6_-_88874597 0.562 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
Podxl2


podocalyxin-like 2


chr18_+_67133713 0.479 ENSMUST00000076605.7
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr5_-_137741601 0.438 ENSMUST00000119498.1
ENSMUST00000061789.7
Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr7_-_74013676 0.429 ENSMUST00000026896.4
St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr7_-_68749170 0.414 ENSMUST00000118110.1
ENSMUST00000048068.7
Arrdc4

arrestin domain containing 4

chr1_-_120120937 0.411 ENSMUST00000151708.1
Dbi
diazepam binding inhibitor
chr7_+_28766747 0.404 ENSMUST00000170068.1
ENSMUST00000072965.4
Sirt2

sirtuin 2

chr11_-_61494173 0.387 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
Mapk7


mitogen-activated protein kinase 7


chr5_-_124187150 0.369 ENSMUST00000161938.1
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr5_-_34187670 0.367 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr3_+_106721893 0.327 ENSMUST00000106736.2
ENSMUST00000154973.1
ENSMUST00000131330.1
ENSMUST00000150513.1
Lrif1



ligand dependent nuclear receptor interacting factor 1



chr2_-_130424242 0.311 ENSMUST00000089581.4
Pced1a
PC-esterase domain containing 1A
chr1_+_171329015 0.308 ENSMUST00000111300.1
Dedd
death effector domain-containing
chr6_+_125039760 0.285 ENSMUST00000140131.1
ENSMUST00000032480.7
Ing4

inhibitor of growth family, member 4

chr2_+_156312589 0.278 ENSMUST00000073942.5
ENSMUST00000109580.1
Cnbd2

cyclic nucleotide binding domain containing 2

chr1_-_120121030 0.260 ENSMUST00000027634.6
Dbi
diazepam binding inhibitor
chr3_+_106721672 0.237 ENSMUST00000098750.2
ENSMUST00000130105.1
Lrif1

ligand dependent nuclear receptor interacting factor 1

chr3_+_51224447 0.229 ENSMUST00000023849.8
ENSMUST00000167780.1
Ccrn4l

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

chr4_-_87230435 0.206 ENSMUST00000107157.2
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr2_-_73892588 0.198 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr2_-_73892619 0.197 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr8_+_3500451 0.195 ENSMUST00000004683.6
ENSMUST00000160338.1
Mcoln1

mucolipin 1

chr17_+_35916541 0.188 ENSMUST00000087211.2
Ppp1r10
protein phosphatase 1, regulatory subunit 10
chr1_-_23383149 0.187 ENSMUST00000027343.5
Ogfrl1
opioid growth factor receptor-like 1
chr2_-_73892530 0.186 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chr2_+_32775769 0.186 ENSMUST00000066352.5
Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr4_+_152178126 0.178 ENSMUST00000075363.3
Acot7
acyl-CoA thioesterase 7
chr8_+_71367210 0.173 ENSMUST00000019169.7
Use1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr6_+_52714219 0.170 ENSMUST00000138040.1
ENSMUST00000129660.1
Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr14_+_79451791 0.168 ENSMUST00000100359.1
Zbtbd6
kelch repeat and BTB (POZ) domain containing 6
chr17_+_24488773 0.167 ENSMUST00000024958.7
Caskin1
CASK interacting protein 1
chr17_+_35916977 0.161 ENSMUST00000151664.1
Ppp1r10
protein phosphatase 1, regulatory subunit 10
chr7_-_132776855 0.155 ENSMUST00000106168.1
Fam53b
family with sequence similarity 53, member B
chr1_+_172082796 0.153 ENSMUST00000027833.5
Copa
coatomer protein complex subunit alpha
chr4_-_132329414 0.148 ENSMUST00000127402.1
ENSMUST00000105962.3
ENSMUST00000030730.7
ENSMUST00000105960.1
Trnau1ap



tRNA selenocysteine 1 associated protein 1



chr13_-_67451585 0.147 ENSMUST00000057241.8
ENSMUST00000075255.5
Zfp874a

zinc finger protein 874a

chr13_-_14613017 0.146 ENSMUST00000015816.3
Mrpl32
mitochondrial ribosomal protein L32
chr8_-_22476809 0.144 ENSMUST00000163774.1
ENSMUST00000033935.8
Smim19

small integral membrane protein 19

chr19_-_8723356 0.142 ENSMUST00000170157.1
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_+_172082509 0.126 ENSMUST00000135192.1
Copa
coatomer protein complex subunit alpha
chr5_+_45520221 0.123 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
Med28


mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)


chr7_+_80261202 0.114 ENSMUST00000117989.1
Ngrn
neugrin, neurite outgrowth associated
chrX_-_74428871 0.113 ENSMUST00000143521.1
G6pdx
glucose-6-phosphate dehydrogenase X-linked
chr11_-_110251736 0.104 ENSMUST00000044003.7
Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr2_-_130424673 0.100 ENSMUST00000110277.1
Pced1a
PC-esterase domain containing 1A
chr2_-_32694120 0.098 ENSMUST00000028148.4
Fpgs
folylpolyglutamyl synthetase
chr12_-_4592927 0.095 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr1_+_57406328 0.088 ENSMUST00000027114.5
9430016H08Rik
RIKEN cDNA 9430016H08 gene
chr7_-_141414115 0.084 ENSMUST00000106008.1
Pddc1
Parkinson disease 7 domain containing 1
chr19_+_5637475 0.079 ENSMUST00000025867.5
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr6_+_52713729 0.077 ENSMUST00000080723.4
ENSMUST00000149588.1
Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr11_-_101302206 0.077 ENSMUST00000140706.1
ENSMUST00000170502.1
ENSMUST00000172233.1
ENSMUST00000130916.1
Becn1



beclin 1, autophagy related



chr13_+_21722057 0.075 ENSMUST00000110476.3
Hist1h2bm
histone cluster 1, H2bm
chr5_-_115348953 0.073 ENSMUST00000040154.8
Cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr5_+_3596066 0.070 ENSMUST00000006061.6
ENSMUST00000121291.1
ENSMUST00000142516.1
Pex1


peroxisomal biogenesis factor 1


chr1_+_58445151 0.059 ENSMUST00000087521.6
ENSMUST00000114337.1
Nif3l1

Ngg1 interacting factor 3-like 1 (S. pombe)

chr6_-_39118211 0.057 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr1_-_172082757 0.057 ENSMUST00000003550.4
Ncstn
nicastrin
chr16_-_56717286 0.041 ENSMUST00000121554.1
ENSMUST00000128551.1
Tfg

Trk-fused gene

chr15_-_98953541 0.035 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr5_+_115631902 0.032 ENSMUST00000031492.8
Rab35
RAB35, member RAS oncogene family
chr5_-_3596071 0.032 ENSMUST00000121877.1
Rbm48
RNA binding motif protein 48
chr1_+_58445531 0.031 ENSMUST00000151272.1
Nif3l1
Ngg1 interacting factor 3-like 1 (S. pombe)
chr2_+_181497223 0.030 ENSMUST00000108799.3
Tpd52l2
tumor protein D52-like 2
chr8_+_84901928 0.030 ENSMUST00000067060.7
Klf1
Kruppel-like factor 1 (erythroid)
chr1_+_163929765 0.025 ENSMUST00000027876.4
ENSMUST00000170359.1
Scyl3

SCY1-like 3 (S. cerevisiae)

chr11_+_78176711 0.024 ENSMUST00000098545.5
Tlcd1
TLC domain containing 1
chr7_+_126976338 0.022 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr2_+_130424321 0.018 ENSMUST00000128994.1
ENSMUST00000028900.9
Vps16

vacuolar protein sorting 16 (yeast)

chr8_-_3621270 0.013 ENSMUST00000159548.1
ENSMUST00000019614.6
Xab2

XPA binding protein 2

chr1_+_120121161 0.010 ENSMUST00000027637.6
ENSMUST00000112644.2
ENSMUST00000056038.8
3110009E18Rik


RIKEN cDNA 3110009E18 gene


chr7_-_101011976 0.010 ENSMUST00000178340.1
ENSMUST00000037540.3
P2ry2

purinergic receptor P2Y, G-protein coupled 2

chr11_+_78536393 0.009 ENSMUST00000050366.8
ENSMUST00000108275.1
Ift20

intraflagellar transport 20

chr7_-_19404082 0.005 ENSMUST00000108458.3
Klc3
kinesin light chain 3
chr11_+_78536355 0.004 ENSMUST00000128788.1
Ift20
intraflagellar transport 20
chr2_-_151973387 0.003 ENSMUST00000109863.1
Fam110a
family with sequence similarity 110, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0021852 pyramidal neuron migration(GO:0021852)
0.5 2.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.2 0.6 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 0.9 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.7 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.4 GO:0070375 ERK5 cascade(GO:0070375)
0.1 0.4 GO:0061428 positive regulation of oocyte development(GO:0060282) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 1.4 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.7 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 0.6 GO:0006537 glutamate biosynthetic process(GO:0006537) proline biosynthetic process(GO:0006561)
0.1 0.3 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 0.2 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:0002034 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) pentose-phosphate shunt, oxidative branch(GO:0009051) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.3 GO:0030157 pancreatic juice secretion(GO:0030157)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.4 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.7 GO:0006970 response to osmotic stress(GO:0006970)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 0.7 GO:0038025 reelin receptor activity(GO:0038025)
0.2 0.7 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 0.5 GO:0050827 toxin receptor binding(GO:0050827)
0.1 0.4 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.2 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.6 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0019172 glyoxalase III activity(GO:0019172)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.6 GO:0042974 retinoic acid receptor binding(GO:0042974)