Motif ID: Klf8

Z-value: 0.645


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.481.4e-02Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 3.022 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr19_+_25610533 2.002 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr6_-_72788952 1.850 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr2_+_172550991 1.657 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr6_+_85187438 1.108 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr3_+_94377432 1.085 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr18_+_74442500 0.976 ENSMUST00000074157.6
 Myo5b
myosin VB
chr7_-_30973464 0.965 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr9_-_8004585 0.959 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr4_-_97778042 0.950 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr3_+_94377505 0.896 ENSMUST00000098877.2
 Rorc
RAR-related orphan receptor gamma
chr13_-_60177357 0.886 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr4_+_46450892 0.874 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_+_87948666 0.842 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr11_-_109473220 0.834 ENSMUST00000070872.6
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr13_-_29984219 0.830 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chrX_+_71050160 0.817 ENSMUST00000082088.3
ENSMUST00000114629.3
 Mamld1

mastermind-like domain containing 1

chr7_-_127026479 0.786 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr13_+_48261427 0.784 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr14_-_8666236 0.751 ENSMUST00000102996.3
 4930452B06Rik
RIKEN cDNA 4930452B06 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 2.0 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.2 2.0 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.6 1.9 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.6 1.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 1.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 1.2 GO:0009299 mRNA transcription(GO:0009299)
0.2 1.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 1.1 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.1 1.1 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 1.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 1.0 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 1.0 GO:0032439 endosome localization(GO:0032439)
0.2 1.0 GO:0060242 contact inhibition(GO:0060242)
0.1 0.9 GO:0042473 outer ear morphogenesis(GO:0042473)
0.0 0.9 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.2 0.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 0.8 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.8 GO:0097421 liver regeneration(GO:0097421)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 1.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.0 GO:0061689 tricellular tight junction(GO:0061689)
0.3 0.9 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 0.7 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 0.5 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.5 GO:0045179 apical cortex(GO:0045179)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.3 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.5 2.0 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.0 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.3 0.8 GO:0005118 sevenless binding(GO:0005118)
0.1 0.8 GO:0019841 retinol binding(GO:0019841)
0.0 0.8 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.7 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 0.6 GO:0070052 collagen V binding(GO:0070052)
0.2 0.5 GO:0017089 glycolipid transporter activity(GO:0017089)
0.1 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)